Takahashi Miho, Aoki Takayuki, Nakamura Naoya, Carreras Joaquim, Kajiwara Hiroshi, Kumaki Nobue, Inomoto Chie, Ogura Go, Kikuchi Tomoki, Kikuti Yara Y, Aoyama Kenichi, Ota Yoshihide
Departments of Oral and Maxillofacial Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Tokai J Exp Clin Med. 2014 Dec 20;39(4):178-85.
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. Distant metastasis (DM) especially bone metastasis (BM) may reduce patients' quality of life and affects the clinical outcome. We performed clinicopathological analysis of 502 patients with OSCC undergoing radical surgery in order to evaluate the correlation values of clinicopathological features for OSCC with special interest in DM. DM was found in 54 cases and among them 44 and 25 cases had pulmonary metastasis (PM) and BM, respectively. Advanced T stage, positive N stage, lower histologic grade and higher score YK classification were the independent significant prognostic factors found in our series of 502 cases of OSCC. Positive lymph node was the most important prognostic factors in DM and BM; on the other hand, in PM, it was lower histological grade. All patients with BM except one had vertebral bone metastasis. These characteristics of DM, including BM and PM, of OSCC are useful for understanding the metastatic process of OSCC.
口腔鳞状细胞癌（OSCC）是口腔最常见的恶性肿瘤。远处转移（DM）尤其是骨转移（BM）可能会降低患者的生活质量并影响临床结局。我们对502例行根治性手术的OSCC患者进行了临床病理分析，以评估OSCC临床病理特征的相关价值，特别关注远处转移。54例患者发现有远处转移，其中分别有44例和25例发生肺转移（PM）和骨转移。在我们这组502例OSCC病例中，T分期较晚、N分期阳性、组织学分级较低以及YK分类评分较高是独立的显著预后因素。阳性淋巴结是远处转移和骨转移最重要的预后因素；另一方面，在肺转移中，最重要的预后因素是组织学分级较低。除1例患者外，所有骨转移患者均有椎骨转移。OSCC的这些远处转移特征，包括骨转移和肺转移，有助于了解OSCC的转移过程。
