Pazhani Jayanthi, Veeraraghavan Vishnu Priya, Jayaraman Selvaraj
Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India.
Bioinformation. 2023 Apr 30;19(4):471-473. doi: 10.6026/97320630019471. eCollection 2023.
Notch signaling is an evolutionarily ancient mechanism which intricated in cell-cell communication and it plays a crucial role in various developments in malignancies. Inactivating mutations of NOTCH targets are present in about 10 % of cases of squamous cell carcinoma of the skin, oral cavity, and esophagus that rendering it one of the most frequently mutated genes in oral squamous cell carcinoma. Therefore, it is of interest to document the molecular docking analysis of cetuximab with the NOTCH signaling targets such as NOTCH1, NICD, and HES1. These results suggest that targeting the NOTCH signaling with cetuximab might leads to the better outcome for suppression of invasion and metastasis in oral carcinoma.
Notch信号通路是一种进化上古老的机制，它参与细胞间通讯，在恶性肿瘤的各种发展过程中起着关键作用。NOTCH靶点的失活突变存在于约10%的皮肤、口腔和食管鳞状细胞癌病例中，这使其成为口腔鳞状细胞癌中最常发生突变的基因之一。因此，记录西妥昔单抗与NOTCH信号靶点（如NOTCH1、NICD和HES1）的分子对接分析很有意义。这些结果表明，用西妥昔单抗靶向NOTCH信号通路可能会为抑制口腔癌的侵袭和转移带来更好的结果。
