Gendelman Samantha R, Lang David M
Department of Clinical Immunology & Allergy, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA,
Curr Allergy Asthma Rep. 2015 Feb;15(2):498. doi: 10.1007/s11882-014-0498-5.
Controversy exists regarding the role of allergen immunotherapy as a therapeutic intervention for patients with atopic dermatitis and aeroallergen sensitivity. Our aim was to critically appraise the evidence supporting the use of sublingual immunotherapy for patients with atopic dermatitis and aeroallergen sensitivity. We performed a literature search using the terms "sublingual immunotherapy" and "atopic dermatitis" and "sublingual immunotherapy" and "eczema." We used the same terms to search PubMed, Ovid, and Scopus. Our limits were "Humans" and "English." We excluded articles that were not in English. These articles were analyzed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Many studies reported improvement in clinical symptoms of atopic dermatitis. Serious methodological shortcomings were noted including but not limited to lack of control group, lack of randomization, incomplete descriptions of randomization and/or allocation concealment, many enrolled subjects not completing participation, and/or data analysis not by intention to treat.
关于变应原免疫疗法作为特应性皮炎和空气变应原敏感患者的一种治疗干预措施的作用，目前存在争议。我们的目的是严格评估支持对特应性皮炎和空气变应原敏感患者使用舌下免疫疗法的证据。我们使用“舌下免疫疗法”和“特应性皮炎”以及“舌下免疫疗法”和“湿疹”等术语进行文献检索。我们使用相同的术语在PubMed、Ovid和Scopus上进行检索。检索限制为“人类”和“英语”。我们排除了非英文文章。这些文章使用推荐分级评估、制定和评价（GRADE）方法进行分析。许多研究报告了特应性皮炎临床症状的改善。但注意到存在严重的方法学缺陷，包括但不限于缺乏对照组、缺乏随机化、随机化和/或分配隐藏描述不完整、许多纳入的受试者未完成参与以及/或者未按意向性治疗进行数据分析。
