Qu Lirong, Triulzi Darrell J
Department of Pathology, Institute for Transfusion Medicine, Pittsburgh, PA 15213, USA.
Cancer Control. 2015 Jan;22(1):26-37. doi: 10.1177/107327481502200105.
Well-characterized biochemical, structural, and physiological changes occur when red blood cells (RBCs) are stored for a period of time and are collectively called the storage lesion.
Key study results are summarized and contrasted and new data from recently completed randomized controlled trials will be discussed.
It is unclear whether in vitro changes to RBCs that occur during storage are clinically relevant. The clinical effects of RBC storage have been the focus of observational studies in recent years. However, these studies lack any consensus, possibly because of methodological limitations.
The clinical significance of storing RBCs is controversial, although new data from randomized controlled trials of neonates and patients undergoing cardiac surgery suggest that the duration of RBC storage is not associated with adverse clinical outcomes in these patient populations.
当红细胞（RBCs）储存一段时间后会发生一系列特征明确的生化、结构和生理变化，这些变化统称为储存损伤。
总结并对比关键研究结果，同时讨论近期完成的随机对照试验的新数据。
尚不清楚储存期间红细胞发生的体外变化是否具有临床相关性。近年来，红细胞储存的临床影响一直是观察性研究的重点。然而，这些研究缺乏任何共识，可能是由于方法学上的局限性。
储存红细胞的临床意义存在争议，尽管来自新生儿和心脏手术患者随机对照试验的新数据表明，在这些患者群体中，红细胞储存时间与不良临床结局无关。
