Madadi Parvaz
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada,
Paediatr Drugs. 2015 Feb;17(1):91-5. doi: 10.1007/s40272-014-0111-3.
Children represent a special population characterized by dynamic changes which may affect drug safety and efficacy. The interplay of pharmacogenetics with physiological alterations that occur throughout development is an area of increasing research focus. Given the translational nature of pharmacogenetic research, it is possible that pharmacogenetic research results may possess clinically actionable information. The potential long-term implications of pharmacogenetic test results throughout the lifespan of the child, and the potential impact of the results for other members of the family need to be considered. Comprehensive counselling and communication strategies may need to be integrated as part of pharmacogenetic research studies in children.
儿童是一个特殊群体，其特点是动态变化，这可能会影响药物的安全性和有效性。药物遗传学与整个发育过程中发生的生理变化之间的相互作用是一个越来越受研究关注的领域。鉴于药物遗传学研究的转化性质，药物遗传学研究结果可能包含具有临床可操作性的信息。需要考虑药物遗传学检测结果在儿童整个生命周期中的潜在长期影响，以及这些结果对家庭其他成员的潜在影响。作为儿童药物遗传学研究的一部分，可能需要整合全面的咨询和沟通策略。
