Mills Rachel, Voora Deepak, Peyser Bruce, Haga Susanne B
Duke Institute for Genome Sciences and Policy, Durham, NC, USA.
Pharmgenomics Pers Med. 2013 Sep 18;6:105-12. doi: 10.2147/PGPM.S50598. eCollection 2013.
Pharmacogenetic testing refers to a type of genetic test to predict a patient's likelihood to experience an adverse event or not respond to a given drug. Despite revision to several labels of commonly prescribed drugs regarding the impact of genetic variation, the use of this testing has been limited in many settings due to a number of factors. In the primary care setting, the limited office time as well as the limited knowledge and experience of primary care practitioners have likely attributed to the slow uptake of pharmacogenetic testing. This paper provides talking points for primary care physicians to discuss with patients when pharmacogenetic testing is warranted. As patients and physicians become more familiar and accepting of pharmacogenetic testing, it is anticipated that discussion time will be comparable to that of other clinical tests.
药物遗传学检测是指一种基因检测，用于预测患者发生不良事件或对某种特定药物无反应的可能性。尽管针对常用处方药的标签就基因变异的影响进行了修订，但由于多种因素，这种检测在许多情况下的应用仍然有限。在初级保健环境中，办公时间有限以及初级保健从业者的知识和经验有限，可能是药物遗传学检测采用率低的原因。本文提供了一些要点，供初级保健医生在有必要进行药物遗传学检测时与患者进行讨论。随着患者和医生对药物遗传学检测越来越熟悉并接受，预计讨论时间将与其他临床检测相当。
