Welle S
Monroe Community Hospital Endocrine-Metabolism Unit, University of Rochester, New York 14603.
J Clin Endocrinol Metab. 1989 Oct;69(4):914-6. doi: 10.1210/jcem-69-4-914.
The relationship between erythrocyte Na,K-ATPase activity (ouabain-inhibited 86Rb uptake) and metabolic efficiency (defined as the resting metabolic rate adjusted for body composition) was examined in 31 healthy young subjects (16 men and 15 women, 19-33 yr old). Mean (+/- SEM) Na,K-ATPase activity (expressed as nanomoles of Rb taken up per h/billion erythrocytes) was similar in the men (86 +/- 3) and women (94 +/- 7). After adjusting metabolic rate for body cell mass (total body potassium), men and women had similar metabolic rates, and subjects with the highest percent body fat tended to have the highest metabolic rates. Ouabain-sensitive erythrocyte Rb uptake was related to less than 2% of the variability in resting metabolic rate after adjusting metabolic rate for differences in body composition. Erythrocyte Na,K-ATPase activity does not appear to be a useful marker of metabolic efficiency in man.
在31名健康的年轻受试者（16名男性和15名女性，年龄在19至33岁之间）中，研究了红细胞钠钾ATP酶活性（哇巴因抑制的86Rb摄取）与代谢效率（定义为根据身体成分调整后的静息代谢率）之间的关系。男性（86±3）和女性（94±7）的平均（±SEM）钠钾ATP酶活性（以每小时/十亿红细胞摄取的Rb纳摩尔数表示）相似。在根据身体细胞质量（全身钾）调整代谢率后，男性和女性的代谢率相似，且体脂百分比最高的受试者往往具有最高的代谢率。在根据身体成分差异调整代谢率后，哇巴因敏感的红细胞Rb摄取与静息代谢率变异性的不到2%相关。红细胞钠钾ATP酶活性似乎不是人类代谢效率的有用标志物。
