基于cullin的泛素E3连接酶的组成、作用及调控
Composition, roles, and regulation of cullin-based ubiquitin e3 ligases.
作者信息
Choi Christina M, Gray William M, Mooney Sutton, Hellmann Hanjo
机构信息
Washington State University, Pullman, Washington.
University of Minnesota, St Paul, Minnesota.
出版信息
Arabidopsis Book. 2014 Nov 17;12:e0175. doi: 10.1199/tab.0175. eCollection 2014.
Due to their sessile nature, plants depend on flexible regulatory systems that allow them to adequately regulate developmental and physiological processes in context with environmental cues. The ubiquitin proteasome pathway, which targets a great number of proteins for degradation, is cellular tool that provides the necessary flexibility to accomplish this task. Ubiquitin E3 ligases provide the needed specificity to the pathway by selectively binding to particular substrates and facilitating their ubiquitylation. The largest group of E3 ligases known in plants is represented by CULLIN-REALLY INTERESTING NEW GENE (RING) E3 ligases (CRLs). In recent years, a great amount of knowledge has been generated to reveal the critical roles of these enzymes across all aspects of plant life. This review provides an overview of the different classes of CRLs in plants, their specific complex compositions, the variety of biological processes they control, and the regulatory steps that can affect their activities.
由于植物固着生长的特性，它们依赖灵活的调控系统，以便能够根据环境线索充分调节发育和生理过程。泛素蛋白酶体途径可靶向大量蛋白质进行降解，是一种能提供必要灵活性以完成此项任务的细胞工具。泛素E3连接酶通过选择性结合特定底物并促进其泛素化，为该途径提供所需的特异性。植物中已知的最大一类E3连接酶以CULLIN-真有趣新基因（RING）E3连接酶（CRLs）为代表。近年来，人们已积累了大量知识，以揭示这些酶在植物生命各个方面的关键作用。本综述概述了植物中不同类别的CRLs、它们特定的复合物组成、它们所控制的各种生物学过程以及可能影响其活性的调控步骤。
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