Levy B I, Benessiano J, Poitevin P, Safar M E
INSERM Unit 141, Hôpital Lariboisière, Paris, France.
J Hum Hypertens. 1989 Jun;3 Suppl 1:57-62.
To investigate the effects of local application of an angiotensin-converting enzyme inhibitor on the mechanical properties of the arterial wall, the volume/pressure relationship (from 25 to 175 mmHg) in the in vivo isolated carotid artery was measured in normotensive (WKY) and spontaneously hypertensive rats (SHR). The compliance of the carotid artery (CC) was calculated, for each level of pressure, as the slope of the the volume/pressure curve. The carotid artery was less compliant in the SHR strain than in normotensive rats. This rigidity was partly related to an increased tone of the arterial smooth muscle in SHR compared with the WKY. Local incubation with lisinopril (2.3 micrograms/ml) produced a significant increase in the compliance of the carotid artery in both normotensive and hypertensive rats; CC was increased by 23% in WKY rats and by 14% in SHR. Since the goal of antihypertensive treatment may be not only to reduce blood pressure (BP) but also to improve the mechanical properties of the arterial system, the direct effect of lisinopril on the arterial wall may have a major beneficial role.
为研究局部应用血管紧张素转换酶抑制剂对动脉壁力学特性的影响，在正常血压（WKY）大鼠和自发性高血压大鼠（SHR）中测量了体内分离的颈动脉的容积/压力关系（25至175 mmHg）。对于每个压力水平，将颈动脉顺应性（CC）计算为容积/压力曲线的斜率。与正常血压大鼠相比，SHR品系的颈动脉顺应性较低。与WKY相比，这种僵硬部分与SHR中动脉平滑肌张力增加有关。用赖诺普利（2.3微克/毫升）进行局部孵育，使正常血压和高血压大鼠的颈动脉顺应性均显著增加；WKY大鼠的CC增加了23%，SHR增加了14%。由于抗高血压治疗的目标可能不仅是降低血压（BP），还包括改善动脉系统的力学特性，赖诺普利对动脉壁的直接作用可能具有重要的有益作用。
