Levy B I, Michel J B, Salzmann J L, Azizi M, Poitevin P, Camilleri J P, Safar M E
INSERM Unit 141, Hôpital Laribosière, Paris, France.
J Hypertens Suppl. 1988 Dec;6(3):S23-5.
The effects of chronic therapy, using an angiotensin converting enzyme (ACE) inhibitor (S9490-3 perindopril, 1 mg/kg), on the mechanical and structural properties of large arteries were studied in two-kidney, one clip (2K, 1C) Goldblatt hypertensive and spontaneously hypertensive rats (SHR) compared with matched normotensive Wistar and Wistar-Kyoto (WKY) animals. The treatment was carried out for 1 month in Goldblatt-hypertensive rats and 3 months in SHR, i.e. for 1 month after blood pressure was normalized. At the end of the treatment period the passive mechanical properties of the isolated carotid artery were measured in situ. Carotid compliance was calculated from the pressure-volume relationship between 50 and 250 mmHg. Morphological parameters of the aortic wall, including medial thickness, nucleus density and elastin and collagen content, were recorded by an automated morphometric system. Renal and essential hypertension were associated with a shift of the passive pressure-volume relationship in the carotid, corresponding to a decrease in arterial compliance. The passive mechanical properties of the carotid were normalized by ACE inhibitor treatment in renovascular hypertensive rats but remained unchanged in chronically treated SHR. The ACE inhibitor completely reversed the medial hypertrophy in Goldblatt-hypertensive rats but the reversal of medial hypertrophy was incomplete in SHR. The elastin to collagen ratio in the aortic media was significantly increased by 3 months of treatment with the ACE inhibitor in the SHR and WKY groups but remained unchanged in the Goldblatt-hypertensive and Wistar rats treated for 1 month.
在两肾一夹（2K，1C）型Goldblatt高血压大鼠和自发性高血压大鼠（SHR）中，研究了使用血管紧张素转换酶（ACE）抑制剂（S9490 - 3培哚普利，1 mg/kg）进行长期治疗对大动脉力学和结构特性的影响，并与匹配的正常血压Wistar大鼠和Wistar - Kyoto（WKY）大鼠进行比较。在Goldblatt高血压大鼠中治疗1个月，在SHR中治疗3个月，即在血压正常化后治疗1个月。在治疗期结束时，原位测量离体颈动脉的被动力学特性。根据50至250 mmHg之间的压力 - 容积关系计算颈动脉顺应性。通过自动形态测量系统记录主动脉壁的形态学参数，包括中膜厚度、细胞核密度以及弹性蛋白和胶原蛋白含量。肾性高血压和原发性高血压与颈动脉被动压力 - 容积关系的改变有关，这对应于动脉顺应性的降低。在肾血管性高血压大鼠中，ACE抑制剂治疗可使颈动脉的被动力学特性恢复正常，但在长期治疗的SHR中则保持不变。ACE抑制剂可完全逆转Goldblatt高血压大鼠的中膜肥厚，但在SHR中中膜肥厚的逆转不完全。在SHR和WKY组中，用ACE抑制剂治疗3个月后，主动脉中膜的弹性蛋白与胶原蛋白的比例显著增加，但在治疗1个月的Goldblatt高血压大鼠和Wistar大鼠中保持不变。
