Ichimura H, Yamasaki M, Tamura I, Kurimura O, Kurimura T
Institute of Clinical Research, Kure National Hospital.
Gan No Rinsho. 1989 Sep;35(10):1133-6.
Out of 16 cases involving a cervical carcinoma that were investigated by Southern blot hybridization, found were human papilloma virus (HPV) types 16 and 18 DNA sequences in 8 (50%) and in one (6.3%), respectively. Six out of the 8 HPV 16-positive specimens were from squamous cell carcinomas, one was from an adenocarcinoma, and the remaining specimen was from an argyrophil small cell carcinoma. In 7 out of 9 HPV-positive specimens, the viral sequences were integrated in the tumor cell genome, whereas in the remaining two they were not integrated and remained circular and/or oligomeric in form.
在通过Southern印迹杂交法研究的16例宫颈癌病例中，分别在8例（50%）和1例（6.3%）中发现了人乳头瘤病毒（HPV）16型和18型DNA序列。8例HPV 16阳性标本中，6例来自鳞状细胞癌，1例来自腺癌，其余标本来自嗜银性小细胞癌。9例HPV阳性标本中，7例的病毒序列整合到了肿瘤细胞基因组中，而其余2例未整合，仍呈环状和/或寡聚体形式。
