[ SOS修复——60年 ]

[SOS-repair--60 years].

作者信息

Zavil'gel'skiĭ G B

出版信息

Mol Biol (Mosk). 2013 Sep-Oct;47(5):699-706.

Abstract

This review integrates 60 years of research on SOS-repair and SOS-mutagenesis in procaryotes and eucaryotes, from Jean Weigle experiment in 1953 year (mutagenesis of lambda bacteriophage in UV-irradiated bacteria) to the latest achievements in studying SOS-mutagenesis on all living organisms--Eukarya, Archaea and Bacteria. A key role in establishing of a biochemical basis for SOS-mutagenesis belonges to the finding in 1998-1999 years that specific error-prone DNA polymerases (PolV and others) catalysed translesion synthesis on damaged DNA. This review focuses on recent studies addressing the new models for SOS-induced mutagenesis in Escherichia coli and Home sapiens cells.

摘要

本综述整合了60年来原核生物和真核生物中关于SOS修复和SOS诱变的研究，从1953年让·韦格尔的实验（紫外线照射细菌中λ噬菌体的诱变）到目前在所有生物体——真核生物、古细菌和细菌中研究SOS诱变的最新成果。1998年至1999年发现特定的易错DNA聚合酶（PolV等）催化受损DNA上的跨损伤合成，这在建立SOS诱变的生化基础中起到了关键作用。本综述重点关注近期关于大肠杆菌和人类细胞中SOS诱导诱变新模型的研究。