Mizutani S, Ito Y, Nomura S, Kurauchi O, Kasugai M, Narita O, Tomoda Y
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
Res Commun Chem Pathol Pharmacol. 1989 Jun;64(3):373-80.
We tested the effects of late pregnancy on the depressor response to bradykinin (100, 200 and 400ng) in rats. All experiments were performed under anesthesia by intraperitoneal injection of pentobarbital (50 mg/kg). Catheters were connected to the arterial and venous lines for blood pressure recording and administration of drugs. Late pregnancy (19- to 21-day) showed a hypersensitivity of the depressor response to bradykinin. The effects of captopril, Kininase II inhibitor, on the depressor response to bradykinin were examined in rats. Since captopril (50, 100 and 200 micrograms) notably increased the depressor response to bradykinin both in nonpregnant and 19- to 21-day pregnant rats, kininase II acts as a bradykinin metabolizing enzyme in vivo. Captopril (50, 100, 200 micrograms), however, resulted in the augmented parallel increases of depressor response to bradykinin (100ng) in both nonpregnant and pregnant rats. Our data may suggest that kininase II is not involved in the hypersensitivity to bradykinin in late pregnancy in rats.
我们测试了妊娠晚期对大鼠缓激肽（100、200和400纳克）降压反应的影响。所有实验均在腹腔注射戊巴比妥（50毫克/千克）麻醉下进行。将导管连接到动脉和静脉线路，用于记录血压和给药。妊娠晚期（19至21天）表现出对缓激肽降压反应的超敏性。在大鼠中研究了缓激肽酶II抑制剂卡托普利对缓激肽降压反应的影响。由于卡托普利（50、100和200微克）在未孕和妊娠19至21天的大鼠中均显著增加了对缓激肽的降压反应，因此缓激肽酶II在体内作为一种缓激肽代谢酶发挥作用。然而，卡托普利（50、100、200微克）导致未孕和妊娠大鼠对缓激肽（100纳克）的降压反应平行增强。我们的数据可能表明，缓激肽酶II不参与大鼠妊娠晚期对缓激肽的超敏反应。
