Yamaguchi Sayaka, Okubo Yuko, Katano Azusa, Sano Ayako, Uezato Hiroshi, Takahashi Kenzo
Department of Dermatology, University of the Ryukyus Graduate School of Medicine, Okinawa, Japan.
J Dermatol. 2015 Feb;42(2):210-4. doi: 10.1111/1346-8138.12736. Epub 2014 Dec 16.
Primary cutaneous mucormycosis is a rare but often lethal severe fungal infection, which usually occurs in immunocompromised patients. We report a case of primary cutaneous mucormycosis caused by Mucor irregularis in an elderly patient. Seven months after the surgical dissection of the involved skin, cutaneous mucormycosis recurred at the peripheral edge of the skin graft. Shortly subsequent to the administration of liposomal amphotericin B, the remaining skin lesion was excised again. M. irregularis is rarely but increasingly reported as a cause of mucormycosis in immunocompetent individuals, especially in Asian farmers. M. irregularis may be largely disseminated in the soils of Asia and thus the trivial trauma at the time of farm work may be a trigger for the onset. These cases tend to leave severe cosmetic damage even in healthy individuals, although the vital prognosis is not affected.
原发性皮肤毛霉病是一种罕见但往往致命的严重真菌感染，通常发生在免疫功能低下的患者中。我们报告了一例由不规则毛霉引起的老年患者原发性皮肤毛霉病。受累皮肤手术切除七个月后，皮肤毛霉病在皮肤移植边缘复发。在给予脂质体两性霉素B后不久，再次切除了剩余的皮肤病变。不规则毛霉作为免疫功能正常个体毛霉病的病因很少见，但报告越来越多，尤其是在亚洲农民中。不规则毛霉可能在亚洲土壤中广泛传播，因此农活时的轻微创伤可能是发病的诱因。这些病例即使在健康个体中也往往会留下严重的美容损伤，尽管不影响生命预后。
