Ette A, Bamba M, Adjoua P, Boguifo J, Ette E E, Fakhry K, Therizol M F
Rev Laryngol Otol Rhinol (Bord). 1989;110(2):173-7.
The authors observed 167 cases of E.N.T. mycoses over a 14-year period (1974-1988) in the E.N.T. Departments of the Abidjan University Hospitals in the Ivory Coast, and in two private health institutions in the city. The majority of cases involve candidiasis (91 cases, or 54.5%), followed by aspergillosis (72 cases, 43.1%) and rhinoentomophtorosis (4 cases, 2.4%). Men are more affected than women (125 as against 42). Men suffering from rhinoentomophtorosis are, for the most part, farmers. Among the contributory factors, we found respectively the abuse of antibiotics, either alone or in association with corticoids for general or local use (ear drops), bathing in lagoons, and diabetes. Bacterial infection is often associated with these mycoses--mainly streptococci and staphylococci aurei. Clinical signs are dominated by pruritus, dull pains, a feeling of fullness in the ear, or of burning in the pharynx. An association of systemic Miconazole and Amphotericin B (local use) has given the best results for candidiasis and aspergillosis. For rhinoentomophtorosis, treatment was long, and even disappointing, until the use of Ketoconazole which may without doubt be considered as the medicament of choice.
作者在1974年至1988年的14年期间,对白喉科医院阿比让大学医院的耳鼻喉科真菌病患者进行了观察,其中167例来自象牙海岸,另外还有两个私立医疗机构的患者。大多数病例为念珠菌病(91例,占54.5%),其次是曲霉菌病(72例,占43.1%)和鼻虫霉病(4例,占2.4%)。男性比女性更容易感染(分别为125例和42例)。患有鼻虫霉病的男性大多是农民。在促成因素中,我们分别发现了滥用抗生素,单独使用或与全身或局部使用的皮质类固醇(滴耳剂)联合使用、在泻湖洗澡和糖尿病。细菌感染通常与这些真菌病有关——主要是链球菌和金黄色葡萄球菌。临床症状主要为瘙痒、隐痛、耳部胀满感或咽部烧灼感。全身性咪康唑和两性霉素B(局部使用)联合使用对白念珠菌病和曲霉菌病疗效最佳。对于鼻虫霉病,治疗时间长,甚至令人失望,直到使用酮康唑,无疑可将其视为首选药物。