Vaijayanthimala V, Lee Dong Keun, Kim Sue V, Yen Albert, Tsai Nathaniel, Ho Dean, Chang Huan-Cheng, Shenderova Olga
Indian Institute of Sciences, Department of Materials Engineering , Karnataka , India.
Expert Opin Drug Deliv. 2015 May;12(5):735-49. doi: 10.1517/17425247.2015.992412. Epub 2014 Dec 16.
The field of nanoparticle-based therapeutic systems is rapidly expanding encompassing a wide variety of practices ranging from detection to diagnosis to treatment. Recently a great potential of nanodiamond (ND) particles as a multimodal imaging/therapy platform has been demonstrated.
This review describes a unique set of properties of ND particles attractive for drug delivery and imaging applications and highlights the most recent ND-based multimodal imaging/therapy approaches and related biocompatibility studies. The spectrum of major advancements includes marked improvements in tumor treatment efficacy and safety based on integration of ND with doxorubicin (DOX). Recent progress of ND-mediated drug delivery in orthopedic, dental and ophthalmic applications is also discussed.
ND particles possess a unique set of properties attractive for drug delivery applications, including exceptional biocompatibility, large carrier capacity and versatile surface chemistry properties, which enhance drug binding and provide sustainable drug release. Other unique attributes of NDs embrace bright stable fluorescence based on crystallographic defects. A roadmap toward a clinical translation comprises identification of ND-therapeutic compounds that display marked improvements over clinical standards with respects to efficacy, safety and cost.
基于纳米颗粒的治疗系统领域正在迅速扩展，涵盖从检测到诊断再到治疗的各种实践。最近，纳米金刚石（ND）颗粒作为多模态成像/治疗平台的巨大潜力已得到证明。
本综述描述了ND颗粒在药物递送和成像应用方面具有吸引力的一组独特特性，并重点介绍了基于ND的最新多模态成像/治疗方法以及相关的生物相容性研究。主要进展包括基于ND与阿霉素（DOX）整合，肿瘤治疗效果和安全性有显著改善。还讨论了ND介导的药物递送在骨科、牙科和眼科应用中的最新进展。
ND颗粒具有一组对药物递送应用具有吸引力的独特特性，包括出色的生物相容性、大载药量和多功能表面化学性质，这些特性增强了药物结合并提供可持续的药物释放。ND的其他独特属性包括基于晶体缺陷的明亮稳定荧光。临床转化的路线图包括识别在疗效、安全性和成本方面比临床标准有显著改善的ND治疗化合物。
