Ho Dean
Division of Oral Biology and Medicine, UCLA School of Dentistry, 10833 Le Conte Avenue, Room B3-068A, Los Angeles, CA, 90095, USA,
Cancer Treat Res. 2015;166:85-102. doi: 10.1007/978-3-319-16555-4_4.
The advent of cancer nanomedicine has forged new pathways for the enhanced imaging and treatment of a broad range of cancers using new classes of materials. Among the many platforms being developed for drug delivery and imaging, nanodiamonds (NDs) possess several important attributes that may be beneficial toward improving the efficacy and safety of cancer nanomedicine applications. These include the uniquely faceted surfaces of the ND particles that result in electrostatic properties that mediate enhanced interactions with water and loaded therapeutic compounds, scalable processing and synthesis parameters, versatility as platform carriers, and a spectrum of other characteristics. In addition, comprehensive in vitro and in vivo studies have demonstrated that NDs are well tolerated. This chapter will examine several recent studies that have harnessed the ND agent as a foundation for both systemic and localized drug delivery, as well as the marked improvements in magnetic resonance imaging efficiency that has been observed following ND-contrast agent conjugation. In addition, insight into the important steps toward bringing the ND translational pathway to the clinic will be discussed.
癌症纳米医学的出现为使用新型材料增强多种癌症的成像和治疗开辟了新途径。在众多用于药物递送和成像的平台中，纳米金刚石（NDs）具有几个重要特性，可能有助于提高癌症纳米医学应用的疗效和安全性。这些特性包括ND颗粒独特的多面表面，其产生的静电特性可介导与水和负载的治疗化合物的增强相互作用、可扩展的加工和合成参数、作为平台载体的多功能性以及一系列其他特性。此外，全面的体外和体内研究表明，NDs具有良好的耐受性。本章将探讨最近的几项研究，这些研究利用ND制剂作为全身和局部药物递送的基础，以及在ND造影剂结合后观察到的磁共振成像效率的显著提高。此外，还将讨论将ND转化途径引入临床的重要步骤。
