Gabbasov Zufar, Sabo Jan, Petrovic Daniel, Martell-Claros Nieves, Zagatina Angela, Mrdovic Igor, Ciccocioppo Rachele, Cangemi Giuseppina Cristina, Klimas Jan, Kruzliak Peter
Institute of Experimental Cardiology, Cardiology Research Center , Moscow , Russia .
Biomarkers. 2015 Feb;20(1):17-25. doi: 10.3109/1354750X.2014.993707. Epub 2014 Dec 16.
In acute myocardial infarction patients the injured vascular wall triggers thrombus formation in the damage site. Fibrin fibers and blood cellular elements are the major components of thrombus formed in acute occlusion of coronary arteries. It has been established that the initial thrombus is primarily composed of activated platelets rapidly stabilized by fibrin fibers. This review highlights the role of platelet membrane phenotype in pathophysiology of myocardial infarction. Here, we regard platelet phenotype as quantitative and qualitative parameters of the plasma membrane outer surface, which are crucial for platelet participation in blood coagulation, development of local inflammation and tissue repair.
在急性心肌梗死患者中，受损的血管壁会在损伤部位引发血栓形成。纤维蛋白纤维和血细胞成分是冠状动脉急性闭塞时形成的血栓的主要组成部分。已经确定，初始血栓主要由被纤维蛋白纤维迅速稳定的活化血小板组成。本综述重点介绍了血小板膜表型在心肌梗死病理生理学中的作用。在此，我们将血小板表型视为质膜外表面的定量和定性参数，这些参数对于血小板参与血液凝固、局部炎症发展和组织修复至关重要。
