Department of Woman, Child and of General and Specialized Surgery, Second University of Studies of Naples, Naples, Italy.
Department of Woman, Child and of General and Specialized Surgery, Second University of Studies of Naples, Naples, Italy.
Taiwan J Obstet Gynecol. 2014 Dec;53(4):494-7. doi: 10.1016/j.tjog.2014.06.001.
Human papillomavirus (HPV) has been recognized as the major etiologic agent of cervical squamous cell carcinoma. However, it has been demonstrated that HPV infection is usually a self-limited process and does not lead to significant epithelial lesions or cancer. Recent data indicate that persistent high-risk HPV (HR-HPV) infections have a significantly increased risk of developing incident high-grade cervical intraepithelial neoplasia and cervical cancer. Our aim, therefore, was to assess whether there exist HPV genotypes whose persistence can be considered powerful surrogates of a progressive disease. We retrospectively selected all patients with a negative cytological diagnosis or with atypical squamous cells of undetermined significance, with a positive test for HR-HPV, different from HPV types 16 and 18, and assessed the significance of the risk of progression based on the persistence of the specific HR-HPV.
We retrospectively queried the database of our Colposcopy Clinic for all patients with a negative cytological diagnosis or with atypical squamous cells of undetermined significance and a positive test for HR-HPV, and we calculated the incidence of progression to lesions greater than or equal to low-grade squamous intraepithelial lesions after 6 months, according to the HPV type.
A progression rate of 48.27% was found in patients tested positive for HPV-31 (Group 1), 38.46% in patients tested positive for HPV-45 (Group 2), and 5.73% in patients tested positive for HPV types other than HPV-16, HPV-18, HPV-31, and HPV-45 (Group 3).
Our data demonstrate that the persistence of HPV-31 and HPV-45 is strongly associated with the occurrence of squamous intraepithelial lesion.
人乳头瘤病毒（HPV）已被确认为宫颈鳞状细胞癌的主要病因。然而，已经证明 HPV 感染通常是一个自限性过程，不会导致明显的上皮病变或癌症。最近的数据表明，持续性高危型 HPV（HR-HPV）感染显著增加了发展为新发高级别宫颈上皮内瘤变和宫颈癌的风险。因此，我们的目的是评估是否存在 HPV 基因型，其持续性可被视为疾病进展的有力替代指标。我们回顾性选择了所有细胞学诊断为阴性或非典型鳞状细胞意义不明确，且 HR-HPV 检测阳性的患者，且 HR-HPV 检测不同于 HPV 16 和 18 型，并根据特定 HR-HPV 的持续性评估进展风险的意义。
我们回顾性查询了我们阴道镜诊所的数据库，以获取所有细胞学诊断为阴性或非典型鳞状细胞意义不明确，且 HR-HPV 检测阳性的患者，并根据 HPV 类型计算了 6 个月后进展为高级别鳞状上皮内病变的发生率。
HPV-31 阳性组（第 1 组）的进展率为 48.27%，HPV-45 阳性组（第 2 组）的进展率为 38.46%，HPV 类型除 HPV-16、HPV-18、HPV-31 和 HPV-45 外的患者阳性组（第 3 组）的进展率为 5.73%。
我们的数据表明，HPV-31 和 HPV-45 的持续性与鳞状上皮内病变的发生密切相关。
