多囊卵巢综合征女性的性取向：台湾的临床观察。

Sexual orientations of women with polycystic ovary syndrome: clinical observation in Taiwan.

机构信息

Department of Obstetrics and Gynecology, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Obstetrics and Gynecology, Taipei Medical University and Hospital, Taipei, Taiwan; Graduate School of Human Sexuality, Shu-Te University, Kaohsiung, Taiwan.

Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, School of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Department of Nursing, National Yang-Ming University, School of Nursing, Taipei, Taiwan.

出版信息

Taiwan J Obstet Gynecol. 2014 Dec;53(4):542-6. doi: 10.1016/j.tjog.2014.09.002.

DOI:10.1016/j.tjog.2014.09.002

PMID:25510698

Abstract

OBJECTIVE

This study was conducted to explore the association between sexual orientations and polycystic ovary syndrome (PCOS)-related parameters.

MATERIALS AND METHODS

A cross-sectional study with participants recruited from the regular outpatient clinic at the Department of Obstetrics and Gynecology at Taipei Medical University Hospital, Taipei, Taiwan between July 2012 and December 2013 was carried out. A total of 97 women met the criterion of having been diagnosed with PCOS. Among these 97 women, 89 were heterosexuals and eight were self-identified as lesbians. At the same time, 78 women without PCOS were enrolled to serve as the control group. Participants were given a standard questionnaire and had blood withdrawn for biochemical analysis of androgen parameters--including total testosterone, androstenedione, sex hormone binding globulin, free androgen index, 17β-estradiol (E2), luteinizing hormone, and follicular-stimulating hormone. The biochemical data were measured to compare the PCOS clinical parameters present in people of different sexual orientations (lesbians and heterosexuals).

RESULTS

The women with PCOS, regardless of sexual orientation, had higher percentages and serum levels of hyperandrogenism-related clinical parameters than the women without PCOS [acne (87.5% and 60.7% vs. 23.1%), p < 0.001]; hirsutism (62.5% and 57.3% vs. 15.4%, p ≤ 0.001)]; and biochemical parameters (total T, p < 0.05 or p < 0.001, and luteinizing hormone/follicular-stimulating hormone ratio, p ≤ 0.001]. The sexual orientation of women with PCOS affected their body mass index (BMI), because lesbians with PCOS possessed higher BMI than heterosexual women with PCOS (26.5 ± 1.9 vs. 22.5 ± 0.55; p < 0.05). However, hyperandrogenism-related clinical and biochemical parameters were not significantly different statistically between women with PCOS but of different sexual orientations.

CONCLUSION

Our preliminary data showed that sexual orientation influenced the BMI of women with PCOS, but did not affect hyperandrogenism-related clinical or biochemical characteristics. This observation requires further confirmation.

摘要

目的

本研究旨在探讨性取向与多囊卵巢综合征（PCOS）相关参数之间的关系。

材料与方法

本研究为横断面研究，于 2012 年 7 月至 2013 年 12 月期间在台北医学大学附属医院妇产科普通门诊招募参与者。共有 97 名符合 PCOS 诊断标准的女性符合入选标准。其中 89 名为异性恋者，8 名为自我认同的女同性恋者。同时，还招募了 78 名没有 PCOS 的女性作为对照组。参与者接受了标准问卷并进行了雄激素参数的生化分析，包括总睾酮、雄烯二酮、性激素结合球蛋白、游离雄激素指数、17β-雌二醇（E2）、黄体生成素和卵泡刺激素。比较不同性取向（女同性恋和异性恋）人群的 PCOS 临床参数，测量生化数据。

结果

无论性取向如何，患有 PCOS 的女性的高雄激素相关临床参数的百分比和血清水平均高于没有 PCOS 的女性[痤疮（87.5%和 60.7%与 23.1%，p<0.001）；多毛症（62.5%和 57.3%与 15.4%，p≤0.001）]；以及生化参数（总 T，p<0.05 或 p<0.001，和黄体生成素/卵泡刺激素比值，p≤0.001）]。患有 PCOS 的女性的性取向影响了她们的体重指数（BMI），因为患有 PCOS 的女同性恋者的 BMI 高于患有 PCOS 的异性恋女性（26.5±1.9 与 22.5±0.55；p<0.05）。然而，性取向不同的 PCOS 女性之间，高雄激素相关的临床和生化参数在统计学上没有显著差异。