Agrawal Rina, Sharma S, Bekir J, Conway G, Bailey J, Balen A H, Prelevic Gordana
The London Women's Clinic and The Hallam Medical Center, London, United Kingdom.
Fertil Steril. 2004 Nov;82(5):1352-7. doi: 10.1016/j.fertnstert.2004.04.041.
To determine the prevalence of polycystic ovaries (PCO) and polycystic ovarian syndrome (PCOS) in lesbian women compared with heterosexual women undergoing fertility treatment.
A prospective observational study.
The London Women's clinic and The Hallam Medical Center. Tertiary referral fertility setup.
PATIENT(S): Six hundred eighteen women undergoing ovarian stimulation with or without IUI treatment between November 2001 and January 2003. Of these, 254 were self-identified as lesbians and 364 were heterosexual women.
INTERVENTION(S): Baseline pelvic ultrasound examination and blood tests conducted to measure biochemical parameters such as FSH, LH, E(2), PRL, T, androstenedione (A), sex hormone-binding globulin (SHBG), and DHEAS were performed between day 2 and 3 of each woman's menstrual cycle. Tubal patency tests were performed by hysterosalpingography or laparoscopy.
MAIN OUTCOME MEASURE(S): Biochemical parameters.
RESULT(S): Eighty percent of lesbian women, compared with 32% of the heterosexual women, had PCO on pelvic ultrasound examination. Thirty-eight percent of lesbian women, compared with 14% of heterosexual women, had PCOS. There were no significant differences in the androgen concentrations between lesbian and heterosexual women with normal ovaries. However, lesbian women with PCO and PCOS had significantly higher androgen concentrations compared with heterosexual women with PCO and PCOS. Tubal disease was as common in lesbian women as in heterosexual women.
CONCLUSION(S): There is a significantly higher prevalence of PCO and PCOS in lesbian compared with heterosexual women. Lesbian women with either PCO or PCOS had more pronounced hyperandrogenism than did heterosexual women with either PCO or PCOS.
确定与接受生育治疗的异性恋女性相比，女同性恋女性中多囊卵巢（PCO）和多囊卵巢综合征（PCOS）的患病率。
一项前瞻性观察研究。
伦敦女子诊所和哈勒姆医疗中心。三级转诊生育机构。
2001年11月至2003年1月期间618名接受卵巢刺激（无论是否进行宫腔内人工授精治疗）的女性。其中，254名自我认定为女同性恋者，364名为异性恋女性。
在每位女性月经周期的第2至3天进行基线盆腔超声检查和血液检测，以测量生化参数，如促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇（E₂）、催乳素（PRL）、睾酮（T）、雄烯二酮（A）、性激素结合球蛋白（SHBG）和硫酸脱氢表雄酮（DHEAS）。通过子宫输卵管造影术或腹腔镜检查进行输卵管通畅性测试。
生化参数。
盆腔超声检查显示，80%的女同性恋女性患有PCO，而异性恋女性为32%。38%的女同性恋女性患有PCOS，异性恋女性为14%。卵巢正常的女同性恋女性和异性恋女性的雄激素浓度无显著差异。然而，患有PCO和PCOS的女同性恋女性的雄激素浓度显著高于患有PCO和PCOS的异性恋女性。输卵管疾病在女同性恋女性和异性恋女性中同样常见。
与异性恋女性相比，女同性恋女性中PCO和PCOS的患病率显著更高。患有PCO或PCOS的女同性恋女性比患有PCO或PCOS的异性恋女性具有更明显的高雄激素血症。
