Liu Yanhong, Pian-Smith May C M, Leffert Lisa R, Minehart Rebecca D, Torri Andrea, Coté Charles, Kacmarek Robert M, Jiang Yandong
Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Jackson 422, Boston, MA, 02114, USA.
J Clin Monit Comput. 2015 Oct;29(5):627-34. doi: 10.1007/s10877-014-9645-8. Epub 2014 Dec 16.
In this study, we aimed to continuously measure cardiac output (CO) with the electrical velocimetry (EV) method and characterize the hemodynamic profile of patients undergoing spinal anesthesia for elective cesarean delivery (CD), and to discuss the potential benefit of using real time CO monitoring to guide patient management. Forty-two patients scheduled for elective CD under spinal anesthesia were enrolled in this observational study. A non-invasive CO monitor incorporating the electrical velocimetry algorithm, ICON(®) (Cardiotronic(®), La Jolla, California, USA), was used to measure CO and stroke volume (SV) continuously. Peripheral venous pressure was measured intermittently at pre-defined time points. Systemic vascular resistance was calculated retrospectively after completion of the study. Hemodynamic changes at pre-defined time points and caused by phenylephrine administration were analyzed. Hypotension (MAP reduction more than 20% from baseline values) occurred in 71.1% of patients after spinal anesthesia, while the coinstantaneous CO was increased ≥20% from baseline in the majority of patients (76.3%) at the same time. Significant increase in CO took place at 3-2 min before the administration of phenylephrine bolus. Treatment of hypotension with phenylephrine was associated with significant decrease in CO. Continuous CO monitoring with EV enables clinicians to determine CO and SV changes prior to onset of hypotension and to better understand patients' hemodynamics. It is an important addition to the current monitoring. The benefit of routinely using this technique remains to be determined in term of the patient outcomes.
在本研究中,我们旨在采用电测速法(EV)持续测量心输出量(CO),并描绘择期剖宫产(CD)行脊髓麻醉患者的血流动力学特征,同时探讨使用实时CO监测指导患者管理的潜在益处。本观察性研究纳入了42例计划在脊髓麻醉下行择期CD的患者。使用一种结合电测速算法的无创CO监测仪ICON(®)(美国加利福尼亚州拉霍亚的Cardiotronic(®)公司)持续测量CO和每搏输出量(SV)。在预先设定的时间点间歇性测量外周静脉压。研究结束后回顾性计算全身血管阻力。分析预先设定时间点以及去氧肾上腺素给药引起的血流动力学变化。脊髓麻醉后71.1%的患者出现低血压(平均动脉压[MAP]较基线值降低超过20%),而与此同时,大多数患者(76.3%)的CO同时较基线升高≥20%。在推注去氧肾上腺素前3 - 2分钟,CO显著增加。用去氧肾上腺素治疗低血压与CO显著降低相关。采用EV持续监测CO可使临床医生在低血压发作前确定CO和SV的变化,并更好地了解患者的血流动力学。这是对当前监测的一项重要补充。就患者预后而言,常规使用该技术的益处仍有待确定。