Jain Hansa, Mulay Sanjyot
Department of Pedodontics, Harsarn Dass Dental College, Ghaziabad, Uttar Pradesh, India.
Indian J Dent Res. 2014 Sep-Oct;25(5):657-61. doi: 10.4103/0970-9290.147118.
Leptin is a polypeptide hormone associated with the occurrence of legion of diseases including obesity, cardiovascular diseases, and diabetes. Periodontitis, that is, inflammation of the periodontium has also been linked to a number of systemic manifestations.
The aim of the present study was to analyze the role of leptin as a biomarker linking periodontitis with obesity, cardiovascular diseases, and diabetes.
The inclusion criteria included, clinical trials available in English language; studies involving human participants; studies relating leptin and periodontal diseases to either obesity, cardiovascular diseases or diabetes. Exclusion criteria enlisted manuscripts in language other than English; if they were case reports, narrative reviews, personal communication, conference presentations, editorial and expert opinion; experiments not involving humans.
We performed a literature search encompassing the time period from January 2000 to May 2013. A systematic search of the Cochrane Library and the Medline through PubMed was performed using the selected keywords/phrases "leptin and periodontitis," "leptin and periodontal diseases," "leptin, periodontitis and obesity," "leptin, periodontitis and cardiovascular diseases," and "leptin, periodontitis, and diabetes."
A total of 23 studies was obtained using the selected keywords/phrases. On screening, the chosen studies seven fulfilled the inclusion criteria. Four demonstrated association of leptin with periodontitis and obesity. One study associated cardiovascular diseases and periodontitis through leptin whereas two were found linking leptin, periodontitis, and diabetes mellitus.
We could find some positive consociation between the serum concentration of leptin, periodontitis, and systemic diseases including obesity and cardiovascular diseases. The results were conflicting when its relation with diabetes mellitus type 2 was examined, as one study favored the association whereas the other one claimed that there was no effect on the levels of leptin.
瘦素是一种多肽激素，与包括肥胖症、心血管疾病和糖尿病在内的多种疾病的发生有关。牙周炎，即牙周组织的炎症，也与许多全身表现有关。
本研究的目的是分析瘦素作为将牙周炎与肥胖症、心血管疾病和糖尿病联系起来的生物标志物的作用。
纳入标准包括：英文的临床试验；涉及人类参与者的研究；将瘦素和牙周疾病与肥胖症、心血管疾病或糖尿病相关联的研究。排除标准包括非英文稿件；如果是病例报告、叙述性综述、个人交流、会议报告、社论和专家意见；不涉及人类的实验。
我们进行了一次文献检索，涵盖2000年1月至2013年5月的时间段。通过PubMed对Cochrane图书馆和Medline进行了系统检索，使用选定的关键词/短语“瘦素与牙周炎”、“瘦素与牙周疾病”、“瘦素、牙周炎与肥胖症”、“瘦素、牙周炎与心血管疾病”以及“瘦素、牙周炎与糖尿病”。
使用选定的关键词/短语共获得23项研究。经筛选，选定的7项研究符合纳入标准。4项研究表明瘦素与牙周炎和肥胖症有关联。1项研究通过瘦素将心血管疾病与牙周炎联系起来，而2项研究发现瘦素、牙周炎和糖尿病之间存在关联。
我们发现瘦素的血清浓度、牙周炎与包括肥胖症和心血管疾病在内的全身性疾病之间存在一些正相关。当研究其与2型糖尿病的关系时，结果相互矛盾，因为一项研究支持这种关联，而另一项研究则声称对瘦素水平没有影响。
