Boyapati Ramanarayana, Chintalapani Srikanth, Ramisetti Arpita, Salavadhi Shyam Sunder, Ramachandran Radhika
Department of Periodontics, Mamata Dental College, Khammam, Telangana, India.
Contemp Clin Dent. 2018 Sep;9(Suppl 2):S210-S214. doi: 10.4103/ccd.ccd_1_18.
Studies have reported changes in leptin and adiponectin levels in the gingival crevicular fluid, saliva, and blood serum of obese patients with periodontal disease. The aim of the study is to evaluate serum leptin and adiponectin levels in obese and nonobese individuals with chronic periodontitis and to deduce a relationship between the clinical parameters and the inflammatory biochemical parameters.
In this case-control study, a total of fifty individuals were selected based on the body mass index (BMI): Group I of obese individuals with chronic periodontitis and Group II of nonobese individuals with chronic periodontitis. Periodontal parameters used in this study were plaque index, gingival index, probing pocket depth, and clinical attachment level. The effects of obesity and periodontal status on serum leptin and adiponectin levels of both groups were statistically analyzed using an independent t- test.
Statistical analysis showed that the effect of BMI on serum leptin and adiponectin levels was statistically significant ( < 0.01), and the effect of chronic periodontitis on the serum leptin and adiponectin levels was also statistically significant compared to nonobese individuals ( < 0.0001). However, there is no statistically significant correlation between serum leptin and adiponectin, which indicates that both are independent to each other.
In obese individuals with chronic periodontitis, serum leptin levels were significantly high compared to nonobese individuals and serum adiponectin levels were significantly lower in obese individuals compared to nonobese individuals with periodontitis, though both the parameters were independent of each other.
研究报告了患有牙周病的肥胖患者龈沟液、唾液和血清中瘦素和脂联素水平的变化。本研究的目的是评估患有慢性牙周炎的肥胖和非肥胖个体的血清瘦素和脂联素水平，并推断临床参数与炎症生化参数之间的关系。
在这项病例对照研究中，根据体重指数（BMI）共选择了50名个体：第一组为患有慢性牙周炎的肥胖个体，第二组为患有慢性牙周炎的非肥胖个体。本研究中使用的牙周参数包括菌斑指数、牙龈指数、探诊袋深度和临床附着水平。使用独立t检验对肥胖和牙周状况对两组血清瘦素和脂联素水平的影响进行统计学分析。
统计分析表明，BMI对血清瘦素和脂联素水平的影响具有统计学意义（<0.01），与非肥胖个体相比，慢性牙周炎对血清瘦素和脂联素水平的影响也具有统计学意义（<0.0001）。然而，血清瘦素和脂联素之间没有统计学上的显著相关性，这表明两者相互独立。
在患有慢性牙周炎的肥胖个体中，与非肥胖个体相比，血清瘦素水平显著升高，与患有牙周炎的非肥胖个体相比，肥胖个体的血清脂联素水平显著降低，尽管这两个参数相互独立。
