Yen Hung-Rong, Sun Mao-Feng, Lin Cheng-Li, Sung Fung-Chang, Wang Chen-Chi, Liang Kai-Li
Research Center for Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan; Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan.
Int Forum Allergy Rhinol. 2015 Mar;5(3):240-6. doi: 10.1002/alr.21446. Epub 2014 Dec 15.
Chronic rhinosinusitis (CRS) is a chronic illness with a high prevalence worldwide. The purpose of this study was to investigate the characteristics of adjunctive traditional Chinese medicine (TCM) use in patients with CRS.
Data were retrieved from a dataset made available by the Taiwan National Health Insurance Research Database (NHIRD) containing the medical records of 1,000,000 randomly sampled beneficiaries insured in the year 2000. Patients newly diagnosed with CRS in the year 2000 were enrolled, and their medical records during the period 2000 to 2011 were collected and analyzed.
A total of 14,806 CRS subjects were enrolled in this study: 10,512 were non-TCM users and 4294 were TCM users. TCM group had a significantly higher proportion of females, were younger, and a greater proportion lived in urban areas compared with the non-TCM group (all p < 0.0001). Ninety-seven percent (97%) of the TCM users received herbal remedies. The most common Chinese herbal formula used was Xin-Yi-Qing-Fei-Tang and the most commonly used single herb was Baizhi. The hazard ratio (HR) for functional endoscopic sinus surgery (FESS) was 0.17 for TCM users (95% confidence interval [CI], 0.15 to 0.20) compared with non-TCM users after adjusting for age, sex, urbanization, and comorbidities.
Our investigation found that 29% of CRS patients used TCM in addition to Western medical treatment. A lower proportion of patients in the TCM group underwent ESS compared with that in the non-TCM group. These findings may be of value in further studies evaluating the efficacy and safety of TCM use in CRS patients.
慢性鼻-鼻窦炎（CRS）是一种在全球范围内具有高患病率的慢性疾病。本研究的目的是调查CRS患者使用辅助性中药（TCM）的特征。
数据取自台湾国民健康保险研究数据库（NHIRD）提供的一个数据集，该数据集包含2000年随机抽样的100万受益人的医疗记录。纳入2000年新诊断为CRS的患者，并收集和分析他们在2000年至2011年期间的医疗记录。
本研究共纳入14806例CRS受试者：10512例为非中药使用者，4294例为中药使用者。与非中药组相比，中药组女性比例显著更高，年龄更小，居住在城市地区的比例更大（所有p<0.0001）。97%的中药使用者接受草药治疗。最常用的中药方剂是辛夷清肺汤，最常用的单味药是白芷。在调整年龄、性别、城市化程度和合并症后，与非中药使用者相比，中药使用者进行功能性鼻内镜鼻窦手术（FESS）的风险比（HR）为0.17（95%置信区间[CI]，0.15至0.20）。
我们的调查发现，29%的CRS患者在西医治疗之外还使用中药。与非中药组相比，中药组接受ESS的患者比例更低。这些发现可能对进一步评估CRS患者使用中药的疗效和安全性的研究有价值。
