Jacke Christian O, Albert Ute S, Reinhard Iris, Kalder Matthias
Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Square J5, 68159, Mannheim, Germany,
J Cancer Res Clin Oncol. 2015 Jun;141(6):1109-18. doi: 10.1007/s00432-014-1879-9. Epub 2014 Dec 16.
To benchmark outcomes of a German breast cancer network with the Surveillance Epidemiology and End Results programme (SEER) of the USA from a longitudinal point of view.
All women receiving primary breast cancer therapy of three hospitals in a rural district of Marburg-Biedenkopf (Germany) of time intervals 1996-1997 and 2003-2004 were used to define local benchmark objects. Data from SEER-programme contributed longitudinal benchmark objects from national level (1988-2004). All benchmark objects were compared with the time-fixed benchmark reference of SEER (2004). Stage distributions and 5-year relative survival ratios were combined to estimate standardized screening-, case-mix-, work-up-, treatment- and relative overall performance index.
From the entry cohort of 877 German women, 97.7 % of the patients accounted for the institutional sample (N = 857) and 65.8 % accounted for the regional sample (N = 577). Stage distributions, relative survival ratios and indices of the German breast cancer network improved over time. Developed indices converged with SEER (2004).
Effectiveness gap between one exemplary German breast cancer network and international benchmark defined by SEER has been closed. Reasons are manifold, and further research is recommended.
从纵向角度将德国乳腺癌网络的结果与美国监测、流行病学和最终结果计划（SEER）进行对比。
1996 - 1997年以及2003 - 2004年期间，德国马尔堡 - 比登科普夫农村地区三家医院接受原发性乳腺癌治疗的所有女性被用于定义当地的基准对象。SEER计划的数据提供了国家层面（1988 - 2004年）的纵向基准对象。所有基准对象均与SEER的固定时间基准参考（2004年）进行比较。结合阶段分布和5年相对生存率来估计标准化筛查、病例组合、检查、治疗和相对总体表现指数。
在877名德国女性的入组队列中，97.7%的患者构成机构样本（N = 857），65.8%的患者构成区域样本（N = 577）。德国乳腺癌网络的阶段分布、相对生存率和指数随时间有所改善。所制定的指数与SEER（2004年）的数据趋于一致。
德国一个示例性乳腺癌网络与SEER定义的国际基准之间的有效性差距已消除。原因是多方面的，建议进一步开展研究。
