Shimizu T, Fujimori M, Takahashi S, Komatsu M, Masuda H, Kobayashi S, Sugenoya A, Senga O, Iida F
Second Dept. of Surgery, Shinshu University.
Gan To Kagaku Ryoho. 1989 Aug;16(8 Pt 2):2707-11.
A total of 15 cases of advanced and recurrent breast cancer of more than 3-year duration were subjected to continuous intra-arterial infusion in our department, and its therapeutic effect and the judgement were examined. Using subclavian artery and internal thoracic artery for the primary cases and the latter artery for the recurrent cases for infusion, continuous administration of 5-FU and one-shot injection of ADM and MMC were performed twice a week. 99mTc-angiography was effective for the identification of arterio-controlled areas. Under the judgement criteria for therapeutic effects according to the breast cancer handling agreement, CR, PR, NC and PD were noted in 1, 8, 5 and 1 cases, respectively, with a 60% rate of effectiveness. Judgement of effects by 201Tl-chloride scintigraphy showed some correlation with the histological judgement, with its apparent effectiveness. Examination of the remote results revealed 3-year survival rate of 83.3% and 3-year healthy survival rate of 66.7% for the primary cases. Two of the 3 recurrent cases died at 2 and 11 post-infusional months, respectively, but 1 showing CR is still alive 4 years and 10 months, post infusionally.
我科对15例病程超过3年的晚期复发性乳腺癌患者进行了动脉内持续灌注，并对其治疗效果及判断进行了研究。对于初治病例采用锁骨下动脉和胸廓内动脉，复发病例采用胸廓内动脉进行灌注，每周两次持续给予5-氟尿嘧啶，一次性注射阿霉素和丝裂霉素。99m锝血管造影对识别动脉控制区域有效。根据乳腺癌处理协议的治疗效果判断标准，分别有1例、8例、5例和1例达到完全缓解（CR）、部分缓解（PR）、无变化（NC）和疾病进展（PD），有效率为60%。氯化铊闪烁显像对疗效的判断与组织学判断有一定相关性，其显效明显。远期结果检查显示，初治病例的3年生存率为83.3%，3年健康生存率为66.7%。3例复发病例中，分别有2例在灌注后2个月和11个月死亡，但1例达到CR的患者在灌注后4年10个月仍存活。
