Fujimori M, Sugenoya A, Kobayashi S, Masuda H, Komatsu M, Takahashi S, Shimizu T, Tsuchiya S, Iida F
Second Dept. of Surgery, Shinsyu University.
Gan To Kagaku Ryoho. 1989 Aug;16(8 Pt 2):2760-3.
An effective immunotherapy for breast cancer has yet to be established. We have recently experienced an inoperable case of advanced breast cancer due to mental disorder. Combined local injection therapy with OK-432 and rIL-2 was performed in addition to non-surgical multi-disciplinary treatment, with obvious therapeutic effects. The case is a 67-year-old female, who had a 5.0 x 4.7 cm tumor in the area A of the left mammary gland. Aspiration cytologic examination revealed class V breast cancer. Besides systemic chemotherapy, local injection therapy with OK-432 2.0 KE on day 1 and rIL-2 500 U on day 3 was performed. Upon starting local injection therapy, a rapid reduction was noted in the tumor diameter (reduction rate, 75.5%). Tumor makers of CEA, CA 15-3 also showed obvious diminution. Although the dose and interval of administration remain to be further examined, the combined local injection therapy with OK-432 and rIL-2 was suggested to be an effective local immunotherapy for breast cancer.
一种有效的乳腺癌免疫疗法尚未确立。我们最近遇到了一例因精神障碍而无法手术的晚期乳腺癌病例。除了非手术多学科治疗外，还进行了OK-432和重组白细胞介素-2联合局部注射治疗，取得了明显的治疗效果。该病例为一名67岁女性，左乳腺A区有一个5.0×4.7厘米的肿瘤。细针穿刺细胞学检查显示为V级乳腺癌。除全身化疗外，第1天进行2.0KE的OK-432局部注射治疗，第3天进行500U的重组白细胞介素-2局部注射治疗。开始局部注射治疗后，肿瘤直径迅速缩小（缩小率为75.5%）。癌胚抗原（CEA）、糖类抗原15-3（CA 15-3）等肿瘤标志物也明显降低。尽管给药剂量和间隔仍有待进一步研究，但OK-432和重组白细胞介素-2联合局部注射治疗被认为是一种有效的乳腺癌局部免疫疗法。
