Sakai Y, Maeda M, Koyama W, Totsuka S, Sakamoto S, Kanayama M
Dept. of Internal Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan.
Gan To Kagaku Ryoho. 1988 Jun;15(6):1978-80.
An 83-year-old patient with advanced gastric cancer was given repeated endoscopic administration of OK-432 combined with systemic immunochemotherapy. The cancerous lesion gradually regressed following the treatment, and remarkable degeneration was observed in many tumor cells. Detailed immunohistochemical examination revealed that Leu 7-positive cells had markedly infiltrated the cancerous tissue. This finding suggests that NK cells may play an important role in tumor regression induced by intratumoral OK-432 therapy.
