Izumi R, Shimizu K, Yabushita K, Watanabe T, Horichi H, Kitabayashi K, Tani T, Urade M, Iyobe T, Segawa M
Dept. of Surgery 2, School of Medicine, Kanazawa University.
Gan To Kagaku Ryoho. 1989 Aug;16(8 Pt 2):2965-8.
Analyses of the prognoses of thirty-four patients with hepatocellular cancer, who were treated by hepatic arterial infusion chemotherapy and/or transcatheter arterial embolization (TAE) and/or hyperthermotherapy, were performed by multivariate analysis using Cox's proportional hazard model and generalized Wilcoxon test. In the multivariate analysis on the conditions of patients, nine of fifteen variables were associated with the prognosis of patients who received regional cancer chemotherapy. The variables are: sex, liver cirrhosis, esophageal varices, GOT, GPT, albumin and gamma-globulin. One of three variables was associated with the prognosis in the therapy analysis, and the variable is TAE. Significant differences in survival curves which were estimated by generalized Wilcoxon test were noted in age, portal vein invasion, ascites, GOT and TAE. From these results it is suggested that the conditions of patients with unresectable hepatocellular cancer must be carefully investigated before regional cancer chemotherapy and the good therapy effects is obtained by hepatic arterial infusion chemotherapy combined with transcatheter arterial embolization therapy.
对34例接受肝动脉灌注化疗和/或经导管动脉栓塞术（TAE）和/或热疗的肝细胞癌患者的预后进行分析，采用Cox比例风险模型和广义Wilcoxon检验进行多因素分析。在对患者情况的多因素分析中，15个变量中的9个与接受区域癌症化疗患者的预后相关。这些变量为：性别、肝硬化、食管静脉曲张、谷草转氨酶（GOT）、谷丙转氨酶（GPT）、白蛋白和γ-球蛋白。在治疗分析中，3个变量中的1个与预后相关，该变量为TAE。通过广义Wilcoxon检验估计的生存曲线在年龄、门静脉侵犯、腹水、GOT和TAE方面存在显著差异。从这些结果表明，在进行区域癌症化疗前必须仔细研究不可切除肝细胞癌患者的情况，并且肝动脉灌注化疗联合经导管动脉栓塞治疗可获得良好的治疗效果。
