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CrossTalk opposing view: The dominant mechanism causing disuse muscle atrophy is proteolysis.相互矛盾的观点：导致废用性肌肉萎缩的主要机制是蛋白水解。
J Physiol. 2014 Dec 15;592(24):5345-7. doi: 10.1113/jphysiol.2014.279406.
2
CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis.相互作用假说：导致废用性肌肉萎缩的主要机制是蛋白质合成减少。
J Physiol. 2014 Dec 15;592(24):5341-3. doi: 10.1113/jphysiol.2014.273615.
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Newton's force as countermeasure for disuse atrophy.牛顿力作为废用性萎缩的应对措施。
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The muscle proteome reflects changes in mitochondrial function, cellular stress and proteolysis after 14 days of unilateral lower limb immobilization in active young men.肌肉蛋白质组在积极的年轻男性单侧下肢固定 14 天后，反映了线粒体功能、细胞应激和蛋白水解的变化。
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Effect of short-term hindlimb immobilization on skeletal muscle atrophy and the transcriptome in a low compared with high responder to endurance training model.短期下肢制动对耐力训练低反应者和高反应者骨骼肌萎缩及转录组的影响。
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本文引用的文献

1
Substantial skeletal muscle loss occurs during only 5 days of disuse.仅在 5 天的不活动期间就会发生大量骨骼肌损失。
Acta Physiol (Oxf). 2014 Mar;210(3):600-11. doi: 10.1111/apha.12190. Epub 2013 Dec 5.
2
Disuse-induced muscle wasting.废用性肌肉萎缩。
Int J Biochem Cell Biol. 2013 Oct;45(10):2200-8. doi: 10.1016/j.biocel.2013.06.011. Epub 2013 Jun 22.
3
Calpain and caspase-3 play required roles in immobilization-induced limb muscle atrophy.钙蛋白酶和半胱天冬酶-3 在固定引起的肢体肌肉萎缩中发挥必需作用。
J Appl Physiol (1985). 2013 May 15;114(10):1482-9. doi: 10.1152/japplphysiol.00925.2012. Epub 2013 Mar 7.
4
Diaphragm muscle thinning in patients who are mechanically ventilated.机械通气患者的膈肌变薄。
Chest. 2012 Dec;142(6):1455-1460. doi: 10.1378/chest.11-1638.
5
Aging affects the transcriptional regulation of human skeletal muscle disuse atrophy.衰老影响人类骨骼肌废用性萎缩的转录调控。
PLoS One. 2012;7(12):e51238. doi: 10.1371/journal.pone.0051238. Epub 2012 Dec 19.
6
The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms.人类肌肉蛋白质组对卧床休息的适应过程及其潜在机制。
J Physiol. 2012 Oct 15;590(20):5211-30. doi: 10.1113/jphysiol.2012.240267. Epub 2012 Jul 30.
7
Cross-talk between the calpain and caspase-3 proteolytic systems in the diaphragm during prolonged mechanical ventilation.在长时间机械通气过程中膈肌中钙蛋白酶和胱天蛋白酶-3 蛋白酶系统的串扰。
Crit Care Med. 2012 Jun;40(6):1857-63. doi: 10.1097/CCM.0b013e318246bb5d.
8
Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse.人膈肌废用导致蛋白水解增加、肌球蛋白耗竭和萎缩 AKT-FOXO 信号传导。
Am J Respir Crit Care Med. 2011 Feb 15;183(4):483-90. doi: 10.1164/rccm.200910-1487OC. Epub 2010 Sep 10.
9
Forty-eight hours of unloading and 24 h of reloading lead to changes in global gene expression patterns related to ubiquitination and oxidative stress in humans.负重 48 小时和再负重 24 小时导致与泛素化和氧化应激相关的人类全基因表达谱发生改变。
J Appl Physiol (1985). 2010 Nov;109(5):1404-15. doi: 10.1152/japplphysiol.00444.2010. Epub 2010 Aug 26.
10
Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy.机械通气导致的人体膈肌废用会引发自噬。
Am J Respir Crit Care Med. 2010 Dec 1;182(11):1377-86. doi: 10.1164/rccm.201002-0234OC. Epub 2010 Jul 16.

CrossTalk opposing view: The dominant mechanism causing disuse muscle atrophy is proteolysis.

作者信息

Reid Michael B, Judge Andrew R, Bodine Sue C

机构信息

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA

Department of Physical Therapy, University of Florida, Gainesville, FL, USA.

出版信息

J Physiol. 2014 Dec 15;592(24):5345-7. doi: 10.1113/jphysiol.2014.279406.

DOI:10.1113/jphysiol.2014.279406
PMID:25512436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4270496/
Abstract
摘要