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CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis.

作者信息

Phillips Stuart M, McGlory Chris

机构信息

Department of Kinesiology, McMaster University, Hamilton, ON, Canada

Department of Kinesiology, McMaster University, Hamilton, ON, Canada.

出版信息

J Physiol. 2014 Dec 15;592(24):5341-3. doi: 10.1113/jphysiol.2014.273615.

DOI:10.1113/jphysiol.2014.273615
PMID:25512435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4270495/
Abstract
摘要

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本文引用的文献

1
A validation of the application of D(2)O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans.应用 D(2)O 稳定同位素示踪技术监测人体肌肉蛋白亚组分合成日常变化的验证。
Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E571-9. doi: 10.1152/ajpendo.00650.2013. Epub 2013 Dec 31.
2
Disuse impairs the muscle protein synthetic response to protein ingestion in healthy men.废用会削弱健康男性肌肉蛋白质合成对蛋白质摄入的反应。
J Clin Endocrinol Metab. 2013 Dec;98(12):4872-81. doi: 10.1210/jc.2013-2098. Epub 2013 Oct 9.
3
Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly.两周的低活动量可减少腿部瘦体重，并导致健康老年人的肌原纤维蛋白合成出现“合成代谢抵抗”。
J Clin Endocrinol Metab. 2013 Jun;98(6):2604-12. doi: 10.1210/jc.2013-1502. Epub 2013 Apr 15.
4
Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults.卧床休息会损害老年人骨骼肌氨基酸转运体的表达、mTORC1 信号转导以及对必需氨基酸的蛋白质合成反应。
Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1113-22. doi: 10.1152/ajpendo.00603.2011. Epub 2012 Feb 14.
5
Post-exercise protein synthesis rates are only marginally higher in type I compared with type II muscle fibres following resistance-type exercise.在抗阻运动后，Ⅰ型肌纤维与Ⅱ型肌纤维相比，运动后蛋白质合成率仅略高。
Eur J Appl Physiol. 2011 Aug;111(8):1871-8. doi: 10.1007/s00421-010-1808-9. Epub 2011 Jan 14.
6
Low-volume resistance exercise attenuates the decline in strength and muscle mass associated with immobilization.低容量抗阻运动可减缓与固定相关的力量和肌肉质量下降。
Muscle Nerve. 2010 Oct;42(4):539-46. doi: 10.1002/mus.21721.
7
A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity.为期2周的动态活动减少会削弱外周胰岛素敏感性。
J Appl Physiol (1985). 2010 May;108(5):1034-40. doi: 10.1152/japplphysiol.00977.2009. Epub 2009 Dec 31.
8
Alterations of protein turnover underlying disuse atrophy in human skeletal muscle.人类骨骼肌废用性萎缩背后蛋白质周转的改变。
J Appl Physiol (1985). 2009 Sep;107(3):645-54. doi: 10.1152/japplphysiol.00452.2009. Epub 2009 Jul 16.
9
Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity.人工重力在21天的模拟微重力环境下维持骨骼肌蛋白质合成。
J Appl Physiol (1985). 2009 Jul;107(1):34-8. doi: 10.1152/japplphysiol.91137.2008. Epub 2009 Apr 23.
10
Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion.制动会在低剂量和高剂量氨基酸输注情况下诱导人体肌原纤维蛋白合成出现合成代谢抵抗。
J Physiol. 2008 Dec 15;586(24):6049-61. doi: 10.1113/jphysiol.2008.160333. Epub 2008 Oct 27.