CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis.
作者信息
Phillips Stuart M, McGlory Chris
机构信息
Department of Kinesiology, McMaster University, Hamilton, ON, Canada
Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
出版信息
J Physiol. 2014 Dec 15;592(24):5341-3. doi: 10.1113/jphysiol.2014.273615.
Abstract
摘要
相似文献
1
CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis.相互作用假说：导致废用性肌肉萎缩的主要机制是蛋白质合成减少。
J Physiol. 2014 Dec 15;592(24):5341-3. doi: 10.1113/jphysiol.2014.273615.
2
CrossTalk opposing view: The dominant mechanism causing disuse muscle atrophy is proteolysis.相互矛盾的观点：导致废用性肌肉萎缩的主要机制是蛋白水解。
J Physiol. 2014 Dec 15;592(24):5345-7. doi: 10.1113/jphysiol.2014.279406.
3
Newton's force as countermeasure for disuse atrophy.牛顿力作为废用性萎缩的应对措施。
J Appl Physiol (1985). 2009 Jul;107(1):6-7. doi: 10.1152/japplphysiol.00499.2009. Epub 2009 May 14.
4
Nutritional strategies to attenuate muscle disuse atrophy.减轻肌肉废用性萎缩的营养策略。
Nutr Rev. 2013 Apr;71(4):195-208. doi: 10.1111/nure.12019. Epub 2013 Feb 28.
5
Not all disuse protocols are equal: new insight into the signalling pathways to muscle atrophy.并非所有的废用方案都是相同的：对肌肉萎缩信号通路的新见解。
J Physiol. 2015 Dec 15;593(24):5227-8. doi: 10.1113/JP271613.
6
Regulation of Protein Synthesis in Inactivated Skeletal Muscle: Signal Inputs, Protein Kinase Cascades, and Ribosome Biogenesis.失活骨骼肌中蛋白质合成的调控：信号输入、蛋白激酶级联反应和核糖体生物发生
Biochemistry (Mosc). 2018 Nov;83(11):1299-1317. doi: 10.1134/S0006297918110020.
7
Mechanisms responsible for disuse muscle atrophy: potential role of protein provision and exercise as countermeasures.导致废用性肌肉萎缩的机制：蛋白质供给和运动作为对抗措施的潜在作用。
Nutrition. 2013 Jan;29(1):22-8. doi: 10.1016/j.nut.2012.04.012. Epub 2012 Aug 28.
8
Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content.肌肉废用性萎缩并不伴有骨骼肌卫星细胞含量的变化。
Clin Sci (Lond). 2014 Apr;126(8):557-66. doi: 10.1042/CS20130295.
9
Rebuttal from Michael B. Reid, Andrew R. Judge and Sue C. Bodine.迈克尔·B·里德、安德鲁·R·贾奇和苏·C·博迪内的反驳意见。
J Physiol. 2014 Dec 15;592(24):5351. doi: 10.1113/jphysiol.2014.284398.
10
Alterations of protein turnover underlying disuse atrophy in human skeletal muscle.人类骨骼肌废用性萎缩背后蛋白质周转的改变。
J Appl Physiol (1985). 2009 Sep;107(3):645-54. doi: 10.1152/japplphysiol.00452.2009. Epub 2009 Jul 16.
引用本文的文献
1
Muscle Aging Heterogeneity: Genetic and Structural Basis of Sarcopenia Resistance.肌肉衰老异质性：肌肉减少症抗性的遗传和结构基础
Genes (Basel). 2025 Aug 11;16(8):948. doi: 10.3390/genes16080948.
2
High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy.高强度有氧运动可预防血管紧张素 II 诱导的肌肉萎缩。
Int Neurourol J. 2025 Jul;29(Suppl 1):S44-S52. doi: 10.5213/inj.2550150.075. Epub 2025 Jul 31.
3
Correlation of Physical Activity Level with Muscle Strength and Size During One Week of Knee Joint Immobilization.膝关节固定一周期间身体活动水平与肌肉力量和大小的相关性
J Funct Morphol Kinesiol. 2025 May 27;10(2):192. doi: 10.3390/jfmk10020192.
4
Mechanisms and Countermeasures for Muscle Atrophy in Microgravity.微重力环境下肌肉萎缩的机制与对策
Cells. 2024 Dec 20;13(24):2120. doi: 10.3390/cells13242120.
5
Nutritional intervention to enhance recovery after arthroscopic knee surgery in adults: a randomized controlled pilot trial.营养干预对成人膝关节镜手术后恢复的促进作用：一项随机对照试验。
Pilot Feasibility Stud. 2024 Nov 12;10(1):138. doi: 10.1186/s40814-024-01561-w.
6
The Influence of Aging on the Unfolded Protein Response in Human Skeletal Muscle at Rest and after Acute Exercise.衰老对静息和急性运动后人体骨骼肌未折叠蛋白反应的影响。
Med Sci Sports Exerc. 2024 Nov 1;56(11):2135-2145. doi: 10.1249/MSS.0000000000003508. Epub 2024 Jun 27.
7
Skeletal Muscle Electrical Stimulation Prevents Progression of Disuse Muscle Atrophy via Forkhead Box O Dynamics Mediated by Phosphorylated Protein Kinase B and Peroxisome Proliferator-Activated Receptor gamma Coactivator-1alpha.骨骼肌电刺激通过磷酸化蛋白激酶B和过氧化物酶体增殖物激活受体γ共激活因子-1α介导的叉头框O动态变化来防止废用性肌肉萎缩的进展。
Physiol Res. 2024 Mar 11;73(1):105-115. doi: 10.33549/physiolres.935157.
8
The effect of protein or amino acid provision on immobilization-induced muscle atrophy in healthy adults: A systematic review and meta-analysis.蛋白质或氨基酸供给对健康成年人固定性肌肉萎缩的影响：系统评价和荟萃分析。
Exp Physiol. 2024 Jun;109(6):873-888. doi: 10.1113/EP090434. Epub 2024 Feb 29.
9
Daily blood flow restriction does not preserve muscle mass and strength during 2 weeks of bed rest.在为期两周的卧床休息期间，每日进行血流限制并不能维持肌肉质量和力量。
J Physiol. 2024 Feb 27. doi: 10.1113/JP286065.
10
Gromwell ameliorates glucocorticoid-induced muscle atrophy through the regulation of Akt/mTOR pathway.紫草通过调节Akt/mTOR信号通路改善糖皮质激素诱导的肌肉萎缩。
Chin Med. 2024 Jan 29;19(1):20. doi: 10.1186/s13020-024-00890-5.
本文引用的文献
1
A validation of the application of D(2)O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans.应用 D(2)O 稳定同位素示踪技术监测人体肌肉蛋白亚组分合成日常变化的验证。
Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E571-9. doi: 10.1152/ajpendo.00650.2013. Epub 2013 Dec 31.
2
Disuse impairs the muscle protein synthetic response to protein ingestion in healthy men.废用会削弱健康男性肌肉蛋白质合成对蛋白质摄入的反应。
J Clin Endocrinol Metab. 2013 Dec;98(12):4872-81. doi: 10.1210/jc.2013-2098. Epub 2013 Oct 9.
3
Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly.两周的低活动量可减少腿部瘦体重，并导致健康老年人的肌原纤维蛋白合成出现“合成代谢抵抗”。
J Clin Endocrinol Metab. 2013 Jun;98(6):2604-12. doi: 10.1210/jc.2013-1502. Epub 2013 Apr 15.
4
Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults.卧床休息会损害老年人骨骼肌氨基酸转运体的表达、mTORC1 信号转导以及对必需氨基酸的蛋白质合成反应。
Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1113-22. doi: 10.1152/ajpendo.00603.2011. Epub 2012 Feb 14.
5
Post-exercise protein synthesis rates are only marginally higher in type I compared with type II muscle fibres following resistance-type exercise.在抗阻运动后，Ⅰ型肌纤维与Ⅱ型肌纤维相比，运动后蛋白质合成率仅略高。
Eur J Appl Physiol. 2011 Aug;111(8):1871-8. doi: 10.1007/s00421-010-1808-9. Epub 2011 Jan 14.
6
Low-volume resistance exercise attenuates the decline in strength and muscle mass associated with immobilization.低容量抗阻运动可减缓与固定相关的力量和肌肉质量下降。
Muscle Nerve. 2010 Oct;42(4):539-46. doi: 10.1002/mus.21721.
7
A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity.为期2周的动态活动减少会削弱外周胰岛素敏感性。
J Appl Physiol (1985). 2010 May;108(5):1034-40. doi: 10.1152/japplphysiol.00977.2009. Epub 2009 Dec 31.
8
Alterations of protein turnover underlying disuse atrophy in human skeletal muscle.人类骨骼肌废用性萎缩背后蛋白质周转的改变。
J Appl Physiol (1985). 2009 Sep;107(3):645-54. doi: 10.1152/japplphysiol.00452.2009. Epub 2009 Jul 16.
9
Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity.人工重力在21天的模拟微重力环境下维持骨骼肌蛋白质合成。
J Appl Physiol (1985). 2009 Jul;107(1):34-8. doi: 10.1152/japplphysiol.91137.2008. Epub 2009 Apr 23.
10
Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion.制动会在低剂量和高剂量氨基酸输注情况下诱导人体肌原纤维蛋白合成出现合成代谢抵抗。
J Physiol. 2008 Dec 15;586(24):6049-61. doi: 10.1113/jphysiol.2008.160333. Epub 2008 Oct 27.
Zotero 插件