Nwiloh Jonathan O, Obialo Chamberlain I
Section of Cardiothoracic Surgery, St. Joseph's Hospital, Atlanta, GA.
Section of Nephrology, Morehouse School of Medicine, Atlanta, GA.
Open J Cardiovasc Surg. 2013 Aug 11;6:21-6. doi: 10.4137/OJCS.S11395. eCollection 2013.
General results of open heart surgery in end-stage renal disease patients (ESRD) have been well-documented. However, it is unknown if the African American subgroup with known decreased access to advanced healthcare services and a higher prevalence rate of ESRD have a worse long-term survival after heart surgery. Thirty of 150 African American patients who underwent open heart surgery by a single surgeon at an urban community hospital between 1996 and 2010 were identified to have ESRD and were on chronic maintenance hemodialysis prior to surgery. Clinical and outcome data from both groups were retrospectively analyzed. There were no significant differences in the baseline demographic characteristics of the patients, but the ESRD cohort showed a significantly higher prevalence of peripheral vascular and cardiovascular diseases [P < 0.001]. Compared to the non-ESRD subjects, the predicted logistic EuroSCORE was 16.4% vs. 9.4%, [P < 0.001], while the observed 30 days operative mortality was 16.6% vs. 4.2% [P < 0.02], respectively. In isolated coronary artery bypass graft cases, operative mortality was 20.8% and 3.0%, respectively. The 5- and 10-year post-surgery survival was 40% and 25% vs. 72% and 57% [P < 0.01], respectively, in the ESRD and non-ESRD groups. Operative mortality and survival was worse in ESRD patients compared to non-ESRD patients based on their preoperative risk scores. Although the operative mortality of our ESRD patients was high, long-term survival was comparable to reports from both the United States Renal Data System and a Japanese ESRD cohort.
终末期肾病(ESRD)患者接受心脏直视手术的总体结果已有充分记录。然而,对于已知获得先进医疗服务机会减少且ESRD患病率较高的非裔美国人亚组,心脏手术后的长期生存率是否更差尚不清楚。在1996年至2010年间,一家城市社区医院由一名外科医生为150名非裔美国人患者实施了心脏直视手术,其中30人被确定患有ESRD,且在手术前接受慢性维持性血液透析。对两组的临床和结局数据进行了回顾性分析。患者的基线人口统计学特征无显著差异,但ESRD队列中周围血管疾病和心血管疾病的患病率显著更高[P<0.001]。与非ESRD受试者相比,预测的逻辑欧洲心脏手术风险评估系统(EuroSCORE)分别为16.4%和9.4%,[P<0.001],而观察到的30天手术死亡率分别为16.6%和4.2%[P<0.02]。在单纯冠状动脉旁路移植术病例中,手术死亡率分别为20.8%和3.0%。ESRD组和非ESRD组术后5年和10年生存率分别为40%和25%,以及72%和57%[P<0.01]。根据术前风险评分,ESRD患者的手术死亡率和生存率比非ESRD患者更差。尽管我们的ESRD患者手术死亡率较高,但其长期生存率与美国肾脏数据系统和一个日本ESRD队列的报告相当。