Frasca Katherine, Cohn Jennifer
J Int Assoc Provid AIDS Care. 2014 Nov-Dec;13(6):534-8.
Current strategies are insufficient to contain the growing tuberculosis (TB) epidemic in areas of high HIV prevalence such as sub-Saharan Africa. Due to the increased risk of morbidity and mortality among those coinfected, early detection is critical. However,strategies dependent on passive, facility-based case finding have failed due to severe limitations in the HIV-positive population.There is growing evidence from multiple clinical trials that early initiation of antiretroviral therapy (ART) in patients coinfected with HIV and TB reduces mortality. Integration of community-based distribution of ART and TB medicines should be considered for coinfected patients to help improve retention in care and to off-load busy health systems. Several models of integration of HIV and TB care in sub-Saharan Africa have been successful. This review article examines the concepts of HIV and TB integration of testing and treatment at the community level.
目前的策略不足以控制撒哈拉以南非洲等高艾滋病毒流行地区不断增长的结核病疫情。由于合并感染人群发病和死亡风险增加,早期检测至关重要。然而,依赖被动的、基于医疗机构的病例发现策略因艾滋病毒阳性人群存在严重局限性而失败。多项临床试验越来越多地证明,艾滋病毒和结核病合并感染患者早期启动抗逆转录病毒疗法(ART)可降低死亡率。对于合并感染患者,应考虑将基于社区的抗逆转录病毒疗法药物和结核病药物分发整合起来,以帮助提高治疗依从性,并减轻繁忙的卫生系统的负担。撒哈拉以南非洲有几种艾滋病毒和结核病综合治疗模式已取得成功。本文综述探讨了社区层面艾滋病毒和结核病检测与治疗整合的概念。