Martins Karen, Cooper Christopher, Warren Travis, Wells Jay, Bell Todd, Raymond Jolynne, Stuthman Kelly, Benko Jacqueline, Garza Nicole, van Tongeren Sean, Donnelly Ginger, Retterer Cary, Dong Lian, Bavari Sina
1 Department of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases (USAMRIID) , Frederick, Maryland.
Viral Immunol. 2015 Feb;28(1):32-41. doi: 10.1089/vim.2014.0085.
The rhesus macaque serves as an animal model for Ebola virus (EBOV) infection. A thorough understanding of EBOV infection in this species would aid in further development of filovirus therapeutics and vaccines. In this study, pathological and immunological data from EBOV-infected rhesus macaques are presented. Changes in blood chemistries, hematology, coagulation, and immune parameters during infection, which were consistently observed in the animals, are presented. In an animal that survived challenge, a delay was observed in the detection of viral RNA and inflammatory cytokines and chemokines which may have contributed to survival. Collectively, these data add to the body of knowledge regarding EBOV pathogenesis in rhesus macaques and emphasize the reproducibility of the rhesus macaque challenge model.
恒河猴作为埃博拉病毒（EBOV）感染的动物模型。深入了解该物种的EBOV感染将有助于丝状病毒治疗药物和疫苗的进一步研发。在本研究中，展示了EBOV感染恒河猴的病理学和免疫学数据。呈现了感染期间动物血液化学、血液学、凝血和免疫参数的变化，这些变化在动物中是一致观察到的。在一只存活下来的受挑战动物中，观察到病毒RNA以及炎症细胞因子和趋化因子的检测出现延迟，这可能有助于其存活。总体而言，这些数据增加了关于恒河猴中EBOV发病机制的知识体系，并强调了恒河猴挑战模型的可重复性。
