Department of Chemistry and ‡Institute for Advanced Materials and Renewable Energy, University of Louisville , Louisville, Kentucky 40292, United States.
Org Lett. 2015 Jan 2;17(1):162-5. doi: 10.1021/ol5033859. Epub 2014 Dec 17.
TiO2-supported nanosize gold particles catalyze the hydration of alkynes using morpholine as a basic cocatalyst. Unlike most homogeneous cationic gold catalysts, the TiO2-Au/morpholine system is weakly basic and is compatible with acid-sensitive functional groups (e.g., silyl ethers, ketals) or with a strongly coordinating group such as pyridine. What's more, this gold catalyst can be recycled by simple filtration and works well in flow reactors.
负载于 TiO2 上的纳米金颗粒可以使用吗啉作为堿性共催化剂催化炔烃的水合反应。与大多数均相阳离子金催化剂不同，TiO2-Au/吗啉体系呈弱堿性，并且可以与酸性敏感官能团（例如硅醚、缩酮）或强配位基团（如吡啶）兼容。此外，这种金催化剂可以通过简单的过滤回收，并在流动反应器中表现良好。
