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一种氯化试剂在多相金催化下高区域选择性生成氯乙烯。

A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis.

机构信息

Department of Chemistry, University of Louisville , Louisville, Kentucky 40292, United States.

College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai 201620, China.

出版信息

Org Lett. 2017 Sep 1;19(17):4524-4527. doi: 10.1021/acs.orglett.7b02101. Epub 2017 Aug 15.

DOI:10.1021/acs.orglett.7b02101
PMID:28809497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5586251/
Abstract

A novel chlorinating reagent with a high concentration of HCl has enabled the highly regioselective hydrochlorination of unactivated alkynes using a commercial nanogold catalyst. No overchlorination or hydration products were formed, and various functional groups were tolerated. This hydrochlorination method could be conducted under open air.

摘要

一种新型高浓度 HCl 的氯化试剂使得使用商业纳米金催化剂能够对未活化的炔烃进行高区域选择性的氯化反应。没有形成过度氯化或水合产物，并且各种官能团都能耐受。这种氯化方法可以在开放空气中进行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445a/5586251/42ec0c2a0494/ol-2017-02101v_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445a/5586251/fe1855539a32/ol-2017-02101v_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445a/5586251/42ec0c2a0494/ol-2017-02101v_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445a/5586251/fe1855539a32/ol-2017-02101v_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445a/5586251/42ec0c2a0494/ol-2017-02101v_0003.jpg

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