Trockel Mickey, Karlin Bradley E, Taylor C Barr, Brown Gregory K, Manber Rachel
Sierra-Pacific Mental Illness Research, Education, and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA.
Stanford University School of Medicine, Palo Alto, CA.
Sleep. 2015 Feb 1;38(2):259-65. doi: 10.5665/sleep.4410.
To examine the effects of cognitive behavioral therapy for insomnia (CBT-I) on suicidal ideation among Veterans with insomnia.
Longitudinal data collected in the course of an uncontrolled evaluation of a large-scale CBT-I training program.
Outpatient and residential treatment facilities.
Four hundred five Veterans presenting for treatment of insomnia.
Cognitive behavioral therapy for insomnia (CBT-I).
At baseline, 32% of patients, compared with 21% at final assessment, endorsed some level of suicidal ideation [χ(2)(df = 1) = 125; P < 0.001]. After adjusting for demographic variables and baseline insomnia severity, each 7-point decrease in Insomnia Severity Index (ISI) score achieved during CBT-I treatment was associated with a 65% (OR = 0.35; 95% CI = 0.24 to 0.52) reduction in odds of suicidal ideation. The effect of change in insomnia severity on change in depression severity was also significant. After controlling for change in depression severity and other variables in the model, the effect of change in insomnia severity on change in suicidal ideation remained significant.
This evaluation of the largest dissemination of CBT-I in the United States found a clinically meaningful reduction in suicidal ideation among Veterans receiving CBT-I. The mechanisms by which effective treatment of insomnia with CBT-I reduces suicide risk are unknown and warrant investigation. The current results may have significant public health implications for preventing suicide among Veterans.
探讨失眠认知行为疗法(CBT-I)对失眠退伍军人自杀意念的影响。
在一项大规模CBT-I培训项目的非对照评估过程中收集的纵向数据。
门诊和住院治疗机构。
405名前来治疗失眠的退伍军人。
失眠认知行为疗法(CBT-I)。
在基线时,32%的患者认可某种程度的自杀意念,而在最终评估时这一比例为21%[χ(2)(自由度 = 1)= 125;P < 0.001]。在对人口统计学变量和基线失眠严重程度进行调整后,CBT-I治疗期间失眠严重程度指数(ISI)得分每降低7分,自杀意念出现几率就降低65%(比值比 = 0.35;95%置信区间 = 0.24至0.52)。失眠严重程度的变化对抑郁严重程度变化的影响也很显著。在控制了抑郁严重程度的变化和模型中的其他变量后,失眠严重程度的变化对自杀意念变化的影响仍然显著。
这项对美国最大规模CBT-I传播情况的评估发现,接受CBT-I治疗的退伍军人自杀意念在临床上有意义地降低。CBT-I有效治疗失眠从而降低自杀风险的机制尚不清楚,值得研究。目前的结果可能对预防退伍军人自杀具有重大的公共卫生意义。