Goudarshivananavar B C, Vigneshwaran V, Dharmappa Kattepura K, Pramod Siddanakoppalu N
Laboratory for Immunomodulation and Inflammation Biology, Department of Studies and Research in Biochemistry, Sahyadri Science College (Autonomous), A Constituent College of Kuvempu University, Shimoga-577 203, Karnataka, India.
Antiinflamm Antiallergy Agents Med Chem. 2015;13(3):165-73. doi: 10.2174/1871523014666141217125732.
Investigation of the pharmacological potential of Tetrahydrofurano/pyrano quinoline and Benzo [b]furoindolyl derivatives in acute inflammation, pain and oxidative stress.
Tetrahydrofurano/ pyrano quinoline and Benzo[b]furoindolyl were evaluated for anti-inflammatory activity by carrageenan-induced hind paw edema in rats. Analgesic activity in mice was assessed by both peripheral and central analgesic models. The free radical scavenging activity of the synthetic compound was analyzed by the in vivo antioxidant assays, by measuring the antioxidant enzymes such as Superoxide dismutase (SOD), Catalase and Peroxidase from the liver homogenate and the in vitro antioxidant activity was evaluated by DPPH photometric assay, Hydroxyl radical scavenging and Lipid Peroxidation assay.
The compounds had substantially inhibited the inflammation induced by subcutaneous carrageenan injection. The same compounds had demonstrated remarkable central and peripheral analgesic activity with potent free radical scavenging activity as evident from both in vitro and in vivo antioxidant assays.
Tetrahydrofurano/pyrano quinoline and Benzo[b]furoindolyl derivatives exhibit varied pharmacological activities that include anti-inflammatory, analgesic and antioxidant activity.
研究四氢呋喃并/吡喃并喹啉及苯并[b]呋喃吲哚基衍生物在急性炎症、疼痛和氧化应激方面的药理潜力。
通过角叉菜胶诱导大鼠后爪水肿来评估四氢呋喃并/吡喃并喹啉及苯并[b]呋喃吲哚基的抗炎活性。通过外周和中枢镇痛模型评估小鼠的镇痛活性。通过体内抗氧化试验分析合成化合物的自由基清除活性，通过测量肝匀浆中的超氧化物歧化酶（SOD）、过氧化氢酶和过氧化物酶等抗氧化酶来进行，体外抗氧化活性通过DPPH光度法、羟自由基清除和脂质过氧化试验进行评估。
这些化合物显著抑制了皮下注射角叉菜胶诱导的炎症。相同的化合物表现出显著的中枢和外周镇痛活性以及强大的自由基清除活性，这从体外和体内抗氧化试验中都很明显。
四氢呋喃并/吡喃并喹啉及苯并[b]呋喃吲哚基衍生物表现出多种药理活性，包括抗炎、镇痛和抗氧化活性。
