Pedersen Frauke, Holz Olaf, Kanniess Frank, Zielen Stefan, Schulze Johannes, Gillissen Adrian, von Berg Andrea, Berdel Dietrich, Beier Jutta, Beeh Kai, Schnoor Maike, Magnussen Helgo
Pulmonary Research Institute at LungClinic Grosshansdorf, Wöhrendamm 80, 22927 Großhansdorf, Germany.
BMC Res Notes. 2014 Dec 17;7:925. doi: 10.1186/1756-0500-7-925.
Asthma is an inflammatory disease of the airways, but in clinical practice inflammation is rarely monitored. The aim of this study was to assess the level of airway inflammation in steroid naïve adult and pediatric patients with intermittent asthma over one year.
54 children and 50 adults with intermittent asthma (GINA step 1) were included. On up to 6 visits lung function, airway hyperresponsiveness to methacholine (PC20FEV1), sputum eosinophils and exhaled nitric oxide (FeNO) were assessed.
36 pediatric and 34 adult patients were able to produce at least three adequate sputum samples over the study period and were included into the analysis.In 8 children (22%) the percentage of sputum eosinophils was always below 2.5%. A higher level of eosinophils (>2.5%) was found on at least one visit in 16 (44%) and always >2.5% in 12 children (33%). In the adult group the respective numbers were 14 patients (41%) with always low (<2.5%), 17 (50%) with at least once over 2.5% and three patients (9%) were always above the threshold of 2.5% sputum eosinophils.
These results demonstrate that a substantial number of children and adults with intermittent asthma under ß-agonist treatment only, have variable or persistently high levels of eosinophilic airway inflammation. Long-term studies are needed to observe the progression of asthma severity in such patient populations.
哮喘是一种气道炎症性疾病，但在临床实践中，炎症很少受到监测。本研究的目的是评估未使用过类固醇的成年和儿童间歇性哮喘患者在一年中的气道炎症水平。
纳入54名儿童和50名成年间歇性哮喘患者（GINA第1级）。在多达6次就诊时，评估肺功能、对乙酰甲胆碱的气道高反应性（PC20FEV1）、痰液嗜酸性粒细胞和呼出一氧化氮（FeNO）。
36名儿童和34名成年患者在研究期间能够提供至少三份合格的痰液样本，并纳入分析。在8名儿童（22%）中，痰液嗜酸性粒细胞百分比始终低于2.5%。在16名儿童（44%）中，至少有一次就诊时嗜酸性粒细胞水平较高（>2.5%），12名儿童（33%）始终>2.5%。在成年组中，相应的数字分别为14名患者（41%）始终较低（<2.5%），17名患者（50%）至少有一次超过2.5%，3名患者（9%）痰液嗜酸性粒细胞始终高于2.5%的阈值。
这些结果表明，大量仅接受β受体激动剂治疗的儿童和成年间歇性哮喘患者，嗜酸性粒细胞气道炎症水平可变或持续较高。需要进行长期研究以观察此类患者群体中哮喘严重程度的进展。
