Sun Yu, Liu Wen-Zhou, Liu Tao, Feng Xu, Yang Nuo, Zhou Hua-Fu
a Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , NanNing , China.
J Recept Signal Transduct Res. 2015;35(5):420-2. doi: 10.3109/10799893.2014.993649. Epub 2014 Dec 17.
Toll-like receptors (TLRs) play a pivotal role in both innate and adaptive immunity, and TLRs recognize invading pathogens through molecular pattern recognition, and ultimately lead to the activation of transcription factors and inflammatory responses. Myocardial infarction leads to changes in the remodeling of the left ventricle of the heart, and the degree and type of remodeling provides important diagnostic information for the therapeutic management of ischemic heart disease. Innate immune takes a most important role in myocardial infarction. There are some studies reporting that TLRs play an important role in the myocardial infarction. The literatures were searched extensively and this review was performed to review the role of TLRs in myocardial infarction.
Toll样受体（TLRs）在固有免疫和适应性免疫中均发挥关键作用，TLRs通过分子模式识别来识别入侵的病原体，并最终导致转录因子的激活和炎症反应。心肌梗死会导致心脏左心室重构的改变，而重构的程度和类型为缺血性心脏病的治疗管理提供重要的诊断信息。固有免疫在心肌梗死中起着至关重要的作用。有一些研究报道TLRs在心肌梗死中发挥重要作用。我们广泛检索了文献，并进行了本综述以探讨TLRs在心肌梗死中的作用。
