Naegeli April N, Flood Emuella, Tucker Jennifer, Devlen Jennifer, Edson-Heredia Emily
Eli Lilly & Co., Indianapolis, IN, USA.
Oxford Outcomes, Bethesda, MD, USA.
Int J Dermatol. 2015 Jun;54(6):715-22. doi: 10.1111/ijd.12645. Epub 2014 Dec 16.
Plaque psoriasis (PP) and psoriatic arthritis (PsA) are autoinflammatory chronic conditions associated with skin involvement. Pruritus, or itching, is a prevalent and bothersome symptom in patients with PP and is associated with reduced health-related quality of life. The Worst Itch Numeric Rating Scale (WI-NRS) has been developed as a simple, single item with which to assess the patient-reported severity of this symptom at its most intense during the previous 24-hour period. Qualitative research was undertaken to assess the content validity of the WI-NRS. Patients with moderate to severe PP and patients with PsA were recruited from clinical sites in the USA. The qualitative research entailed two-part interviews, which began with concept elicitation to gain understanding of patients' experiences of itching, followed by cognitive debriefing of the WI-NRS to assess the instrument's understandability, clarity, and degree of appropriateness from the patient's perspective. Twelve patients with PP and 22 with PsA participated in the study. Patients reported that itching was an important and relevant symptom of their psoriatic disease. The WI-NRS was reported to be complete and easy to understand; the recall period was considered appropriate, the response scale was familiar, and, overall, the instrument was found to be appropriate for assessing itching severity. Patient responses support the content validity of the WI-NRS. The psychometric properties of the tool will be evaluated in future studies.
斑块状银屑病（PP）和银屑病关节炎（PsA）是与皮肤受累相关的自身炎症性慢性病。瘙痒是PP患者中普遍且令人烦恼的症状，与健康相关生活质量下降有关。最差瘙痒数字评定量表（WI-NRS）已被开发出来，作为一个简单的单项量表，用于评估患者报告的在前24小时内该症状最严重时的严重程度。开展了定性研究以评估WI-NRS的内容效度。从中度至重度PP患者和PsA患者中招募研究对象，这些患者来自美国的临床机构。定性研究包括两部分访谈，首先是概念引出，以了解患者的瘙痒经历，然后是对WI-NRS进行认知反馈，从患者角度评估该量表的可理解性、清晰度和适当程度。12名PP患者和22名PsA患者参与了该研究。患者报告称，瘙痒是其银屑病的一个重要且相关的症状。据报告，WI-NRS完整且易于理解；回忆期被认为合适，反应量表为人熟知，总体而言，该量表被认为适合评估瘙痒严重程度。患者的回答支持WI-NRS的内容效度。该工具的心理测量特性将在未来研究中进行评估。
