Maldonado Galdeano Carolina, Novotny Nuñez Ivanna, Carmuega Esteban, de Moreno de LeBlanc Alejandra, Perdigón Gabriela
Centro de Referencia para Lactobacilos (CERELA-CONICET). Chacabuco 145, San Miguel de Tucuman (T4000ILC) Tucuman. Argentina.
Endocr Metab Immune Disord Drug Targets. 2015;15(1):37-45. doi: 10.2174/1871530314666141216121349.
There are numerous reports that show the benefits on the health attributed to the probiotic consumptions. Most of the studies were performed using animal models and only some of them were validated in controlled human trials. The present review is divided in two sections. In the first section we describe how the probiotic microorganisms can interact with the intestinal epithelial cells that are the first line of cell in the mucosal site, focusing in the studies of two probiotic strains: Lactobacillus casei DN-114001 (actually Lactobacillus paracasei CNCMI-1518) and Lactobacillus casei CRL 431. Then we describe same beneficial effects attributed to probiotic administration and the administration of fermented milks containing these microorganisms or potential probiotic yoghurt, principally on the immune system and on the intestinal barrier in different experimental mouse models like enteropathogenic infection, malnutrition, cancer and intestinal inflammation.
有大量报告显示食用益生菌对健康有益。大多数研究是使用动物模型进行的，其中只有一些在人体对照试验中得到验证。本综述分为两个部分。在第一部分中，我们描述了益生菌微生物如何与肠道上皮细胞相互作用，肠道上皮细胞是黏膜部位的第一道防线，重点关注两种益生菌菌株的研究：干酪乳杆菌DN-114001（实际上是副干酪乳杆菌CNCMI-1518）和干酪乳杆菌CRL 431。然后我们描述了益生菌给药以及含有这些微生物或潜在益生菌酸奶的发酵乳给药所带来的相同有益效果，主要是在不同的实验小鼠模型中，如肠道致病性感染、营养不良、癌症和肠道炎症，对免疫系统和肠道屏障的影响。
