Jiao K R, Zhang S M, Xu K C
Zhonghua Xin Xue Guan Bing Za Zhi. 1989 Apr;17(2):96-8, 127.
The levels of plasma kininase II (ACE), a high molecular weight-kininogen (HMW), alpha 2-mega-globular protein (alpha 2M), prekallikrein (PK), alpha 1-antitrypsin (alpha 1 AT) were determined in essential hypertension and control groups. The results showed that there is significant increase of ACE and PK activity and HMW content in patients with essential hypertension than in control group (P less than 0.001). No changes in alpha 2M and alpha 1AT were found. These results suggest that human plasma kallikrein system was inhibited in patients with essential hypertension.
在原发性高血压组和对照组中测定了血浆激肽释放酶II（血管紧张素转换酶，ACE）、高分子量激肽原（HMW）、α2-巨球蛋白（α2M）、前激肽释放酶（PK）、α1-抗胰蛋白酶（α1AT）的水平。结果显示，原发性高血压患者的ACE和PK活性以及HMW含量比对照组显著升高（P<0.001）。未发现α2M和α1AT有变化。这些结果提示，原发性高血压患者的人血浆激肽释放酶系统受到抑制。
