Karpitskiĭ V V
Vopr Med Khim. 1984 Sep-Oct;30(5):110-3.
Estimations of prekallikrein and kallikrein inhibitor by means of TAME-esterase method and of the content of kininogen by biological procedure were carried out in blood plasma, isolated from right and left ventricles of heart, of rats with spontaneous hypertension, Okamoto-Aoki strain, and of the normotensive animals Wistar-Kyoto strain. The animals were 2=3 months, 6=8 months and 12=14 months old. Development of spontaneous hypertension was accompanied by an increase in the kallikrein-kinin system components studied. Content of prekallikrein and kininogen was higher in blood plasma from left heart ventricle than in blood from right ventricle, independently of the age of the rats, by 6=10% and 33=40%, respectively. Lung tissue was shown to carry out a definite reserve function in the compensatory increase of the kallikrein-kinin system potential under conditions of spontaneous hypertension.
采用TAME酯酶法对来自冈本-青木株自发性高血压大鼠以及正常血压的Wistar-Kyoto株大鼠心脏左右心室的血浆中前激肽释放酶和激肽释放酶抑制剂进行了测定，并通过生物学方法对激肽原含量进行了测定。这些动物年龄为2至3个月、6至8个月和12至14个月。自发性高血压的发展伴随着所研究的激肽释放酶-激肽系统成分的增加。大鼠左心室血浆中前激肽释放酶和激肽原的含量高于右心室血浆，与大鼠年龄无关，分别高出6%至10%和33%至40%。结果表明，在自发性高血压情况下，肺组织在激肽释放酶-激肽系统潜能的代偿性增加中发挥着一定的储备功能。
