Fassbender C M, Büchsel R, Seelis R, Hofstädter F, Matern S
Medizinische Klinik III, Rheinisch-Westfälischen Technischen Hochschule, Aachen.
Dtsch Med Wochenschr. 1989 Sep 22;114(38):1445-9. doi: 10.1055/s-2008-1066781.
A 53-year-old woman had suffered from watery diarrhoea and substitution-requiring hypokalaemia for 18 months. Ultrasonography and abdominal x-ray revealed multiple calcifications in the liver. Retrograde cholangiopancreaticography, performed because an endocrine-secreting pancreatic tumour was suspected, demonstrated occlusion of the major pancreatic duct and calcification in the body of the pancreas. Gastrointestinal hormone levels were elevated (vasoactive intestinal polypeptide 950 pg/ml, pancreatic polypeptide 1000 pmol/l and neurotensin 86 pmol/l) in the blood, and immunohistochemical results on cells of an adenocarcinoma obtained by needle biopsy confirmed a metastasizing VIPoma. Administration of the somatostatin analogue SMS 201-995 achieved marked improvement.
一名53岁女性出现水样腹泻和需要补钾的低钾血症18个月。超声检查和腹部X线显示肝脏有多处钙化。因怀疑有内分泌分泌性胰腺肿瘤而进行的逆行胰胆管造影显示主胰管阻塞和胰体钙化。血液中胃肠激素水平升高（血管活性肠肽950 pg/ml、胰多肽1000 pmol/l和神经降压素86 pmol/l），经皮针吸活检获得的腺癌细胞免疫组化结果证实为转移性血管活性肠肽瘤。给予生长抑素类似物SMS 201-995后病情明显改善。
