中东和北非非洲之角次区域丙型肝炎病毒（HCV）流行率和发病率的系统评价与荟萃分析方案
Protocol for a systematic review and meta-analysis of hepatitis C virus (HCV) prevalence and incidence in the Horn of Africa sub-region of the Middle East and North Africa.
作者信息
Chaabna Karima, Mohamoud Yousra A, Chemaitelly Hiam, Mumtaz Ghina R, Abu-Raddad Laith J
机构信息
Infectious Disease Epidemiology Group, Weill Cornell Medical College-Qatar, Cornell University, Qatar Foundation-Education City, Doha, Qatar.
出版信息
Syst Rev. 2014 Dec 16;3:146. doi: 10.1186/2046-4053-3-146.
BACKGROUND
In the Middle East and North Africa (MENA), hepatitis C virus (HCV) distribution appears to present a wide range of prevalence. The scale and nature of HCV disease burden is poorly known in the Horn of Africa sub-region of MENA including Djibouti, Somalia, and Sudan in addition to Yemen at the southwest corner of the Arabian Peninsula. The aim of this review is to provide a systematic review and synthesis of all epidemiological data on HCV prevalence and incidence among the different population groups in this sub-region of MENA. A second aim of the study is to estimate the national population-level HCV prevalence for each of these four countries.
METHODS/DESIGN: The systematic review will be conducted based on the items outlined in the PRISMA statement. PubMed, Embase, and the World Health organization (WHO) regional databases will be searched for eligible studies without language or date restrictions. Observational and intervention studies reporting data on the prevalence or incidence of HCV in any population group in Djibouti, Somalia, Sudan, or Yemen will be included. Additional sources will be obtained through the database of the MENA HIV/AIDS Epidemiology Synthesis Project, including international organizations' reports and country-level reports, and abstracts of international conferences. Study and population characteristics will be extracted from eligible publications, with previously agreed pro formas; and entered into a computerized database. We will pool prevalence using DerSimonian and Laird random-effects models after a Freeman-Tukey transformation to stabilize variances. We will conduct meta-regression analysis to explore the effect of study-level characteristics as potential sources of heterogeneity.
DISCUSSION
This proposed systematic review and meta-analysis aims to better describe HCV infection distribution across countries in the Horn of Africa sub-region of MENA; and between sub-population groups within each country. The study will provide empirical evidence necessary for researchers, policy-makers, and public health stakeholders to set research, policy, and programming priorities for HCV prevention, control, and treatment.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42014010318.
背景
在中东和北非地区（MENA），丙型肝炎病毒（HCV）的分布呈现出广泛的流行率范围。除了阿拉伯半岛西南角的也门之外，MENA的非洲之角次区域（包括吉布提、索马里和苏丹）的HCV疾病负担的规模和性质鲜为人知。本综述的目的是对MENA该次区域不同人群中HCV流行率和发病率的所有流行病学数据进行系统综述和综合分析。该研究的第二个目的是估计这四个国家各自的全国人口水平的HCV流行率。
方法/设计：将根据PRISMA声明中概述的项目进行系统综述。将检索PubMed、Embase和世界卫生组织（WHO）区域数据库以查找符合条件的研究，无语言或日期限制。将纳入报告吉布提、索马里、苏丹或也门任何人群中HCV流行率或发病率数据的观察性和干预性研究。其他来源将通过MENA艾滋病毒/艾滋病流行病学综合项目的数据库获得，包括国际组织的报告和国家层面的报告以及国际会议摘要。将使用先前商定的表格从符合条件的出版物中提取研究和人群特征，并输入计算机化数据库。在进行Freeman-Tukey变换以稳定方差后，我们将使用DerSimonian和Laird随机效应模型汇总流行率。我们将进行meta回归分析，以探讨研究层面特征作为异质性潜在来源的影响。
讨论
这项拟议的系统综述和荟萃分析旨在更好地描述MENA非洲之角次区域各国以及每个国家内亚人群体之间的HCV感染分布情况。该研究将为研究人员、政策制定者和公共卫生利益相关者设定HCV预防、控制和治疗的研究、政策和规划优先事项提供必要的经验证据。
系统综述注册
PROSPERO CRD42014010318
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