溶剂选择对芴甲氧羰基-二苯基丙氨酸的凝胶化及最终水凝胶性质的影响。
The effect of solvent choice on the gelation and final hydrogel properties of Fmoc-diphenylalanine.
作者信息
Raeburn Jaclyn, Mendoza-Cuenca Cristina, Cattoz Beatrice N, Little Marc A, Terry Ann E, Zamith Cardoso Andre, Griffiths Peter C, Adams Dave J
机构信息
Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK.
出版信息
Soft Matter. 2015 Feb 7;11(5):927-35. doi: 10.1039/c4sm02256d.
Gels can be formed by dissolving Fmoc-diphenylalanine (Fmoc-PhePhe or FmocFF) in an organic solvent and adding water. We show here that the choice and amount of organic solvent allows the rheological properties of the gel to be tuned. The differences in properties arise from the microstructure of the fibre network formed. The organic solvent can then be removed post-gelation, without significant changes in the rheological properties. Gels formed using acetone are meta-stable and crystals of FmocFF suitable for X-ray diffraction can be collected from this gel.
通过将芴甲氧羰基-二苯基丙氨酸（Fmoc-苯丙氨酸苯丙氨酸或FmocFF）溶解在有机溶剂中并加水，可以形成凝胶。我们在此表明，有机溶剂的选择和用量可以调节凝胶的流变性质。性质上的差异源于所形成的纤维网络的微观结构。然后可以在凝胶形成后除去有机溶剂，而流变性质不会发生显著变化。使用丙酮形成的凝胶是亚稳态的，可以从这种凝胶中收集适合X射线衍射的FmocFF晶体。
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