计算机断层扫描灌注成像作为结直肠癌的潜在影像学生物标志物
Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer.
作者信息
Hayano Koichi, Fujishiro Takeshi, Sahani Dushyant V, Satoh Asami, Aoyagi Tomoyoshi, Ohira Gaku, Tochigi Toru, Matsubara Hisahiro, Shuto Kiyohiko
机构信息
Koichi Hayano, Dushyant V Sahani, Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States.
出版信息
World J Gastroenterol. 2014 Dec 14;20(46):17345-51. doi: 10.3748/wjg.v20.i46.17345.
Abstract
Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer (CRC), and the importance of angiogenesis in cancer progression has been established. Computed tomography (CT) perfusion (CTP) based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer kinetics. CTP has been reported to characterize tumor angiogenesis, and to be a sensitive marker for predicting recurrence or survival in CRC. In this review, we will discuss the biomarker value of CTP in the management of CRC patients.
摘要
据报道，在结直肠癌（CRC）的腺瘤-癌序列中，新生血管形成在早期就会出现，并且血管生成在癌症进展中的重要性已经得到证实。基于高时间分辨率CT图像的计算机断层扫描（CT）灌注（CTP）能够通过对示踪剂动力学进行建模来评估体内组织的血流动力学。据报道，CTP能够表征肿瘤血管生成，并且是预测CRC复发或生存的敏感标志物。在本综述中，我们将讨论CTP在CRC患者管理中的生物标志物价值。
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