Lupo I, Daniele O, Raimondo D, Rodolico V, Camarda R M
Institute of Neuropsychiatry, University of Palermo, Italy.
Eur Neurol. 1989;29(5):269-72. doi: 10.1159/000116425.
We observed a patient with the hypereosinophilic syndrome that showed as a prominent clinical feature peripheral nerve dysfunction. The neuropathy evolved over 4 months and affected sensory and motor functions. Nerve conduction studies and EMG were compatible with axonal neuropathy. Nerve and muscle biopsies revealed severe axonal degeneration with neurogenic atrophy of muscle. Morphometry of peroneal nerve showed marked axonal loss, more prominent in large myelinated fibers. There was no evidence of vasculitis process. Neuropathy is produced by eosinophil-released substances exerting a neurotoxic effect through direct altered vascular endothelial permeability and local mast cell histamine release.
我们观察了一名患有高嗜酸性粒细胞综合征的患者，其主要临床特征为周围神经功能障碍。神经病变在4个月内逐渐发展，影响了感觉和运动功能。神经传导研究和肌电图与轴索性神经病变相符。神经和肌肉活检显示严重的轴索变性伴肌肉神经源性萎缩。腓总神经形态测量显示明显的轴索丢失，在大的有髓纤维中更为突出。没有血管炎的证据。神经病变是由嗜酸性粒细胞释放的物质通过直接改变血管内皮通透性和局部肥大细胞组胺释放而产生神经毒性作用所致。
